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              A Phase 1, First-in-human, Randomized, Double-blind, Placebo-controlled, Single and Multiple Ascending Intravenous Dose Study of a novel TREM2 agonist (VGL101) in Healthy Volunteers (HVs)

              Author:Papapetropoulos, Spyridon   Meier, Andreas   O'Mara, Ryan   Marsh, Andrew   Neelon, Kelly   Rajagovindan, Rajasimhan   Thackaberry, Evan   Stiles, David   

              Session Name:S14: General Neurology: Emerging Therapies  

              Topic:General Neurology  

              Program Number:S14.004  

              Author Institution:Vigil Neuroscience, Cambridge, MA  Consultant, Cambridge, MA  

              A Prospective Natural History Study of Patients with Adult-Onset Leukoencephalopathy with Axonal Spheroids and Pigmented Glia (ALSP)

              Author:Rajagovindan, Raj   Matys, Benjamin   Finger, Elizabeth   Gelfand, Jeffrey   Isaacson, Stuart   Köhler, Wolfgang   Kumar, Rajeev   Lynch, David   Orthmann-Murphy, Jennifer   Schöls, Ludger   Wolf, Nicole   Meier, Andreas   Papapetropoulos, Spyridon   Wszolek, Zbigniew   

              Session Name:S49: General Neurology  

              Topic:General Neurology  

              Program Number:S49.008  

              Author Institution:Vigil Neuroscience, Cambridge, MA  Western University, London, ON, Canada  University of California, San Francisco, CA  Parkinson’s Disease and Movement Disorders Center of Boca Raton, Boca Raton, FL  University of Leipzig Medical Center, Leipzig, Germany  Rocky Mountain Movement Disorders Center, Englewood, CO  University College London, London, United Kingdom  University of Pennsylvania, Philadelphia, PA  University of Tuebingen, Tuebingen, Germany  Department of Child Neurology, Amsterdam Leukodystrophy Center, Emma Children’s Hospital, Amsterdam University Medical Centers, VU University, and Amsterdam Neuroscience, Amsterdam, Netherlands  Mayo Clinic- Jacksonville, Jacksonville, FL  

              Refining the phenotype of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP), a commonly misdiagnosed autosomal dominant neurodegenerative disease

              Author:Papapetropoulos, Spyridon   Marsh, Andrew   Meier, Andreas   Rajagovindan, Rajasimhan   Leahy, Leslie   O'Mara, Ryan   Wszolek, Zbigniew   

              Session Name:S49: General Neurology  

              Topic:General Neurology  

              Program Number:S49.010  

              Author Institution:Vigil Neuroscience, Cambridge, MA  Consultant, Cambridge, MA  Vigil Neuroscience, Winchester, MA  Vigil Neuroscience, Quincy, MA  Mayo Clinic- Jacksonville, Jacksonville, FL  

              Radiological features of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) and its longitudinal progression

              Author:Rajagovindan, Rajasimhan   O’Mara, Ryan   Meier, Andreas   MacDougall, James   Finger, Elizabeth   Orthmann-Murphy, Jennifer   Broderick, Daniel   Wszolek, Zbigniew   Papapetropoulos, Spyros   

              Session Name:P8: General Neurology: Neuroimaging  

              Topic:General Neurology  

              Program Number:P8.003  

              Author Institution:Vigil Neuroscience, Winchester, MA  Vigil Neuroscience, Cambridge, MA  Senior Statistical Consultant, Cambridge, MA  LHSC, London, ON, Canada  University of Pennsylvania, Philadelphia, PA  Mayo Clinic, Jacksonville, FL  Mayo Clinic- Jacksonville, Jacksonville, FL  

              Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is commonly misdiagnosed as Frontotemporal Dementia (FTD), Multiple Sclerosis (MS,) Alzheimer’s disease (AD), or other adult-onset leukodystrophies

              Author:Meier, Andreas   Leahy, Leslie   Pontius, Angela   Zappia, Samantha   Brennan, Matthew   Papapetropoulos, Spyridon   Wszolek, Zbigniew   

              Session Name:P12: General Neurology: Neurogenetics 2  

              Topic:General Neurology  

              Program Number:P12.003  

              Author Institution:Vigil Neuroscience, Quincy, MA  ACP Clinical, Boston, MA  Vigil Neuroscience, Cambridge, MA  Consultant, Andover, MA  Vigil Neuroscience , Cambridge, MA  Mayo Clinic- Jacksonville, Jacksonville, FL