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Cdk5 inhibition in the SOD1G93A transgenic mouse model of amyotrophic lateral sclerosis suppresses neurodegeneration and extends survival.

Author:Kim, Ahwon   Lee, Do-Yeon   Sung, Jung-Joon   

Session Name:P1: Aging and Dementia: Basic Science  

Topic:Aging and Dementia  

Program Number:P1.001  

Author Institution:Seoul National University Hospital, Seoul, Korea, Republic of  Seoul National University, Seoul, Korea, Republic of  

Hexanucleotide repeat expansions in C9orf72 alter microglial responses and prevent a coordinated glial reaction in ALS

Author:Masrori, Pegah   Bijnens, Baukje   Davie, Kristofer   Poovathingal, Suresh Kumar   Storm, Annet   Hersmus, Nicole   Fumagalli, Laura   Van Den Bosch, Ludo   Fiers, Mark   Thal, Dietmar   Mancuzo, Renzo   Van Damme, Philip   

Session Name:P1: Aging and Dementia: Basic Science  

Topic:Aging and Dementia  

Program Number:P1.002  

Author Institution:University Hospitals Leuven, Leuven, Belgium  VIB, Antwerp, Belgium  VIB, Leuven, Belgium  UZ Leuven, Leuven, Belgium  

RACK1 Knockdown is a Potential Therapeutic Target in ALS and FTLD-TDP

Author:Cashman, Neil   Zhao, Beibei   Cowan, Catherine   Saraph, Ananya   Christy, Darren   Coutts, Juliane   Kaplan, Johanne   

Session Name:P1: Aging and Dementia: Basic Science  

Topic:Aging and Dementia  

Program Number:P1.003  

Author Institution:ProMIS Neurosciences, Vancouver, BC, Canada  University of British Columbia, Vancouver, BC, Canada  ProMIS Neurosciences, Sherborn, MA  

Aqueously diffusible RNA-bound amyloid-ß aggregates in Alzheimer disease brain

Author:Stern, Andrew   Meunier, Angela   Liu, Wen   Selkoe, Dennis   

Session Name:P1: Aging and Dementia: Basic Science  

Topic:Aging and Dementia  

Program Number:P1.004  

Author Institution:Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Boston, MA  

Single-cell RNA analysis reveals cell-specific increases in SUR1-related pathway activity with age in murine brain.

Author:Xiong, Zujian   Sneiderman, Chaim   Rajasundaram, Dhivyaa   Simon, Dennis   Catapano, Joshua   Rulney, Jarrod   Raikwar, Sudhanshua   Rani, Anupama   Shahjouei, Shima   Mihaljevic, Sandra   Winkler, Ethan   Janesko-Feldman, Keri   Trivedi, Ria   Vagni, Vincent   Kochanek, Patrick   Jha, Ruchira   Kohanbash, Gary   

Session Name:P1: Aging and Dementia: Basic Science  

Topic:Aging and Dementia  

Program Number:P1.005  

Author Institution:University of Pittsburgh, Pittsburgh, PA  Barrow Neurological Institute, Phoenix, AZ