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              A Phase 1, First-in-human, Randomized, Double-blind, Placebo-controlled, Single and Multiple Ascending Intravenous Dose Study of a novel TREM2 agonist (VGL101) in Healthy Volunteers (HVs)

              Author:Papapetropoulos, Spyridon   Meier, Andreas   O'Mara, Ryan   Marsh, Andrew   Neelon, Kelly   Rajagovindan, Rajasimhan   Thackaberry, Evan   Stiles, David   

              Session Name:S14: General Neurology: Emerging Therapies  

              Topic:General Neurology  

              Program Number:S14.004  

              Author Institution:Vigil Neuroscience, Cambridge, MA  Consultant, Cambridge, MA  

              Refining the phenotype of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP), a commonly misdiagnosed autosomal dominant neurodegenerative disease

              Author:Papapetropoulos, Spyridon   Marsh, Andrew   Meier, Andreas   Rajagovindan, Rajasimhan   Leahy, Leslie   O'Mara, Ryan   Wszolek, Zbigniew   

              Session Name:S49: General Neurology  

              Topic:General Neurology  

              Program Number:S49.010  

              Author Institution:Vigil Neuroscience, Cambridge, MA  Consultant, Cambridge, MA  Vigil Neuroscience, Winchester, MA  Vigil Neuroscience, Quincy, MA  Mayo Clinic- Jacksonville, Jacksonville, FL