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              Rational design of a vaccine for Alzheimer’s disease using computationally-derived conformational B cell epitopes to selectively target toxic amyloid-beta oligomers

              Author:Kaplan, Johanne   Napper, Scott   Scruten, Erin   Gibbs, Ebrima   Coutts, Juliane   Cashman, Neil   

              Session Name:S26: Experimental Therapeutics in Dementia  

              Topic:Aging and Dementia  

              Program Number:S26.004  

              Author Institution:ProMIS Neurosciences, Sherborn, MA  University of Saskatchewan, Sakatoon, SK, Canada  University of British Columbia, Vancouver, BC, Canada  UBC, Vancouver, BC, Canada  

              Using Predictive Models to Reduce Heterogeneity in Alzheimer’s Disease Clinical Trials

              Author:Ezzati, Ali   Petersen, Kellen   Nallapu, Bhargav   Lipton, Richard   

              Session Name:S26: Experimental Therapeutics in Dementia  

              Topic:Aging and Dementia  

              Program Number:S26.005  

              Author Institution:Albert Einstein College of Medicine, Great neck, NY  Albert Einstein College of Medicine, Bronx, NY  

              ALUMNI AD Study Design: Evaluation of Subcutaneous Gantenerumab in Historically Underrepresented US Populations With Early Symptomatic Alzheimer’s Disease

              Author:Seleri, Sheila   Brangman, Sharon   Henderson, J. Neil   Parker, Monica   Monroe, Stephanie   Mintzer, Jacobo   Wise-Brown, Alexandria   Grundman, Michael   Smith, Janice   Doody, Rachelle   Lin, Helen   Assman, Beverly   Rippon, Gregory   

              Session Name:S26: Experimental Therapeutics in Dementia  

              Topic:Aging and Dementia  

              Program Number:S26.006  

              Author Institution:Genentech, Inc., a member of the Roche Group, South San Francisco, CA  SUNY Upstate Medical University, Syracuse, NY  University of minnesota, Minneapolis, MN  Goizueta Alzheimer’s Disease Research Center, Emory University School of Medicine, Atlanta, GA  UsAgainstAlzheimer's, Washington, DC, DC  Medical University of South Carolina, Charleston, SC  Global R&D Partners, LLC, San Diego, CA  F. Hoffmann-La Roche Ltd., Basel, Switzerland  

              Effects of ALZ-801, an Oral Amyloid Oligomer Inhibitor, on Biomarkers of Alzheimer’s Disease (AD): 12-Month Results of Phase 2 Biomarker Study in Early AD

              Author:Hey, John   Abushakra, Susan   Blennow, Kaj   Scheltens, Philip   Hort, Jakub   Sheardova, Katerina   Prins, Niels   Rutgers, Sterre   Dautzenberg, Paul   Pazdera, Ladislav   Kesslak, Patrick   Mandelbaum, Rosalind   Power, Aidan   Tolar, Martin   

              Session Name:S26: Experimental Therapeutics in Dementia  

              Topic:Aging and Dementia  

              Program Number:S26.007  

              Author Institution:Alzheon, Inc., Framingham, MA  Institute of Neuroscience & Physiology & Neurochemistry Laboratory, Molndal, Sweden  Amsterdam University Medical Centers, Amsterdam, Netherlands  Charles University Department of Neurology, Prague, Czech Republic  Memory Center, St. Anne University Hospital & International Clinical Research Center , Brno, Czech Republic  Brain Research Center, Amsterdam, Netherlands  Brain Research Center, Den Bosch, Netherlands  Vestra Research Clinics, Rychnov and Kneznou, Czech Republic  

              Fosgonimeton Provides Congruent Improvements on Neurodegeneration Biomarkers, Significantly Correlating With Composite Clinical Score of Cognition and Function in Alzheimer’s Disease

              Author:Moebius, Hans   Ooi, Kai-Bin   Hale, Michael   Setti, Sharay   Kleist, Kayla   Bernick, Charles   

              Session Name:S26: Experimental Therapeutics in Dementia  

              Topic:Aging and Dementia  

              Program Number:S26.008  

              Author Institution:Athira Pharma, Inc., Bothell, WA  Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV