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Blood Biomarker Dynamics in Highly Active Relapsing Multiple Sclerosis Patients Treated With Cladribine Tablets: Results of the 2-Year MAGNIFY-MS Study

Author:Wiendl, Heinz   De Stefano, Nicola   Barkhof, Frederik   Montalban, Xavier   Achiron, Anat   Derfuss, Tobias   Chan, Andrew   Hodgkinson, Suzanne   Prat, Alexandre   Leocani, Letizia   Schmierer, Klaus   Sellebjerg, Finn   Vermersch, Patrick   Jin, Hulin   Jarvinen, Elina   Chudecka, Anita   Gardner, Lidia   

Session Name:S16: MS Clinical Trials and Therapeutics  

Topic:MS and Inflammatory Disease  

Program Number:S16.006  

Author Institution:University of Muenster, Muenster, Germany  Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy  VU University Medical Center, Amsterdam, Netherlands  Centre d’Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitario Vall d’Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain  Multiple Sclerosis Center, Sheba Academic Medical Center, Ramat Gan, Israel  University Hospital Basel, Basel, Switzerland  Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland  Ingham Institute for Applied Medical Research, University of New South Wales Medicine, Sydney, Australia  Université de Montréal, Montreal, QC, Canada  Experimental Neurophysiology Unit, Vita-Salute San Raffaele University, Milan, Italy  The Blizard Institute, Centre for Neuroscience, Surgery & Trauma, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, United Kingdom  Copenhagen University Hospital - Rigshospitalet, Glostrup, Denmark  Inserm U1172 LilNCog, CHU Lille, FHU Precise, Lille, France  the healthcare business of Merck KGaA, Darmstadt, Germany, Darmstadt, Germany  Cytel Inc. Geneva, Switzerland, Geneva, Switzerland  EMD Serono, Billerica, MA, USA, Billerica, MA  

Effect of Longer-term Ofatumumab Treatment on Disability Progression and Brain Volume Change

Author:Cohen, Jeffrey   Hauser, Stephen   Zielman, Ronald   Das Gupta, Ayan   Azmon, Amin   Xi, Jing   Mavrikis Cox, Gina   Robertson, Derrick   Wiendl, Heinz   Kappos, Ludwig   

Session Name:S16: MS Clinical Trials and Therapeutics  

Topic:MS and Inflammatory Disease  

Program Number:S16.009  

Author Institution:Department of Neurology, Mellen MS Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA, Cleveland, OH  UCSF Weill Institute for Neurosciences, Department of Neurology, University of California - San Francisco, San Francisco, CA, USA, San Francisco, CA  Central Texas Neurology Consultants, Round Rock, TX, USA, Round Rock, TX  Novartis Pharma B.V., Amsterdam, The Netherlands, Haaksbergweg, Netherlands  Novartis Healthcare Pvt. Ltd., Hyderabad, India, Hyderabad, India  Novartis Pharma A.G., Basel, Switzerland, Basel, Switzerland  China Novartis Institutes for BioMedical Research Co., Ltd, Shanghai, China, Shanghai, China, People's Republic of  Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA, East Hanover, NJ  Multiple Sclerosis Division, Department of Neurology, University of South Florida, Tampa, FL, USA, Tampa, FL  University of Muenster, Muenster, Germany, Muenster, Germany  Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB) and MS Center, Departments of Head, Spine and Neuromedicine, Clinical Research, Biomedicine and Biomedical Engineering, University Hospital and University of Basel, Basel, Switzerland, Basel, Switzerland  

Identification of multiple sclerosis endophenotypes by high dimensional blood signatures associated with distinct disease trajectories

Author:Gross, Catharina C   Schulte-Mecklenbeck, Andreas   Steinberg, Olga V   Wirth, Timo   Lauks, Sarah   Baranzini, Sergio E   Bittner, Stefan   Bellmann-Strobl, Judith   Bünger, Nora   Eilers, Eva   Eveslage, Maria   Fleischer, Vinzenz   Gisevius, Barbara   Groppa, Sergiu   Haas, Jürgen   Kerschensteiner, Martin   Kirstein, Lucienne   Korsukewitz, Catharina   Lohmann, Lisa   Lünemann, Jan   Lüssi, Felix   Meyer zu Hörste, Gerd   Motte, Jeremias   Ruck, Tobias   Schwab, Nicholas   Meuth, Sven G   Paul, Friedemann   Wildemann, Brigitte   Kümpfel, Tania   Gold, Ralf   Zipp, Frauke   Klotz, Luisa   Wiendl, Heinz   

Session Name:P1: MS Biomarkers  

Topic:MS and Inflammatory Disease  

Program Number:P1.008  

Author Institution:University Hospital Münster, Münster, Germany  University of California San Francisco, San Francisco, CA  University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany  Max Delbrueck Center for Molecular Medicine and Charité Universitätsmedizin Berlin, Berlin, Germany  University of Münster, Münster, Germany  University Hospital Bochum, Bochum, Germany  University of Heidelberg, Heidelberg, Germany  Ludwig Maximilians University of Munich, Munich, Germany  University and University Hospital of Münster, Münster, Germany  Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany  Charite Universitatsmedizin in Berlin, Berlin, Germany  University Hospital Heidelberg, Heidelberg, Germany