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PRAX-562 is a Well-Tolerated, Novel Persistent Sodium Channel Blocker with Broad Anticonvulsant Activity in Multiple DEE Mouse Models

Author:Anderson, Lyndsey   Jancovski, Nikola   Eckert, William   Baker, Erin   Wagley, Pravin   Maljevic, Snezana   Reid, Christopher   Patel, Manoj   Kearney, Jennifer   Kahlig, Kristopher   Petrou, Steven   

Session Name:S34: Child Neurology and Developmental Neurology 2  

Topic:Child Neurology and Developmental Neurology  

Program Number:S34.007  

Author Institution:Praxis Precision Medicines, Boston, MA  Florey Institute of Neuroscience and Mental Health, Parkville, Australia  Northwestern University Feinberg School of Medicine, Chicago, IL  University of Virginia Health System, Charlottesville, VA  

A Novel Approach to Assess the Impact of Disease in Patients with SCN8A-Related Developmental and Epileptic Encephalopathy

Author:Dalby, Kelley   Snyder, Ted   Matthews, Lillian   Oldham, Michael   Petrou, Steven   Souza, Marcio   

Session Name:P3: Child Neurology and Developmental Neurology: Seizures 1  

Topic:Child Neurology and Developmental Neurology  

Program Number:P3.008  

Author Institution:Praxis Precision Medicines, Boston, MA  

PRAX-562-102: A Phase?1 Trial Evaluating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of PRAX-562 in Healthy Volunteers

Author:Mahalingam, Rajeshwari   Oldham, Michael   Puryear, Corey   Bansal, Prashant   Sriram, Balaji   Patel, Dharit   Jacotin, Henry   Hard, Marjie   Arefayene, Million   Ravina, Bernard   Souza, Marcio   Petrou, Steven   

Session Name:P4: Child Neurology and Developmental Neurology: Seizures 2  

Topic:Child Neurology and Developmental Neurology  

Program Number:P4.011  

Author Institution:Praxis Precision Medicines, Boston, MA  

PRAX-628 is a Novel, Well-Tolerated, Activity Dependent Sodium Channel Blocker with Potent Anticonvulsant Activity

Author:Eckert, William   Kahlig, Kristopher   Anderson, Lyndsey   Petrou, Steven   

Session Name:P4: Child Neurology and Developmental Neurology: Seizures 2  

Topic:Child Neurology and Developmental Neurology  

Program Number:P4.012  

Author Institution:Praxis Precision Medicines, Boston, MA  

PRAX-562-101: A Phase?1 Trial Evaluating the Safety, Tolerability, Pharmacokinetics and Food Effect of PRAX-562 in Healthy Volunteers

Author:Pfister, Brian   Mahalingam, Rajeshwari   Oldham, Michael   Patel, Dharit   Jacotin, Henry   Hard, Marjie   Puryear, Corey   Ravina, Bernard   Souza, Marcio   Petrou, Steven   

Session Name:P8: Child Neurology and Developmental Neurology: Seizures 3  

Topic:Child Neurology and Developmental Neurology  

Program Number:P8.011  

Author Institution:Praxis Precision Medicines, Boston, MA