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The Bruton’s Tyrosine Kinase Inhibitor Evobrutinib Demonstrates Superior Efficacy in Targeting Compartmentalized Neuroinflammation Compared to Anti-CD20 Treatment.

Author:Kebir, Hania   Li, Cen   May, Michael   Church, Molly   Boschert Shafaatian, Ursula   Alvarez, Jorge   

Session Name:S16: MS Clinical Trials and Therapeutics  

Topic:MS and Inflammatory Disease  

Program Number:S16.004  

Author Institution:University of Pennsylvania, Philadelphia, PA  C/o Serono, Geneva, Switzerland  University of Pennsylvania, Philadelpha, PA  

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Evobrutinib therapeutic response is associated with an increase in the number and maturation of peripheral and central classical dendritic cells

Author:Clemente, Diego   Serrano-Regal, Mari Paz   Calahorra, Leticia   Alonso-García, Inmaculada   Boschert Shafaatian, Ursula   Haselmayer, Philipp   Ortega, Cristina   Machín-Díaz, Isabel   Camacho-Toledano, Celia   García-Arocha, Jennifer   

Session Name:P7: MS Therapeutics 1  

Topic:MS and Inflammatory Disease  

Program Number:P7.005  

Author Institution:1Neuroimmuno-Repair Group. Research Unit. Hospital Nacional de Parapléjicos-SESC, Toledo, Spain  2Ares Trading SA, Eysins, Switzerland, an affiliate of Merck KGaA, Geneva, Switzerland  3Merck KGaA, Darmstadt, Germany , Darmstadt, Germany  

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