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Earliest Description of Endemic Amyotrophic Lateral Sclerosis (ALS) in Kii Peninsula in Japan as “Endemic Paraplegia of Koza in Kii” Published in 1689 Honcho Koji Innen Shu—A Religious Treatise Based on Oral Histories Recorded for Posterity Identified by

Vitamin E (Alpha-tocopherol) Central Nervous System (CNS) Effects [Increasing Ramified Microglia; Decreasing Astrocytosis; Decreasing Oxidative Stress Biomarkers; Slowing Amyotrophic Lateral Sclerosis (ALS) Progression from Early to Advanced Disease] and

Smartphone Software Application-mediated At-home Telespirometry (AHT) Artificial Intelligence(AI)-algorithm Identifies Similar Proportion of Valid Erect (eFVC) and Supine (sFVC) Forced Vital Capacity Measurements and Comparable per Subject Test-ReTest Var