Disclosures for "The Integrated Stress Response Is Modulated by eIF2B Agonist DNL343: Results From Phase 1 Healthy Subject and Phase 1b ALS Patient Studies.")
		
	
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			Dr. Sun has nothing to disclose.
		
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			Dr. Tsai has received personal compensation for serving as an employee of Denali Therapeutics. Dr. Tsai has stock in Denali Therapeutics. 
		
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			Dr. Yulyaningsih has received personal compensation for serving as an employee of Denali Therapeutics. Dr. Yulyaningsih has stock in Denali Therapeutics. Dr. Yulyaningsih has stock in 23 & ME. Dr. Yulyaningsih has stock in Ardelyx. Dr. Yulyaningsih has stock in Amylyx. 
		
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			Dr. Fanok has received personal compensation for serving as an employee of Denali Therapeutics .  An immediate family member of Dr. Fanok has received personal compensation in the range of $0-$499 for serving as an officer or member of the Board of Directors for Cincor Pharma. Dr. Fanok has stock in Denali Therapeutics. 
		
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			Mr. Vissers has received personal compensation for serving as an employee of Centre for Human Drug Research. 
		
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			Dr. Heuberger has received personal compensation for serving as an employee of Centre for Human Drug Research. 
		
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			Dr. Flores has nothing to disclose.
		
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			Fen Huang has nothing to disclose.
		
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			Dr. Kane has received personal compensation for serving as an employee of Denali Therapeutics. Dr. Kane has stock in Denali Therapeutics. 
		
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			Dr. Cohen has received personal compensation for serving as an employee of Denali. Dr. Cohen has stock in Denali. 
		
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			Dr. Dhuria has received personal compensation for serving as an employee of Denali Therapeutics. Dr. Dhuria has stock in Denali Thereapeutics. 
		
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			Dr. Fang has received personal compensation for serving as an employee of Denali Therapeutics. Dr. Fang has stock in Denali therapeutics. 
		
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			Dr. Estrada has stock in Denali Therapeutics . 
		
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			Dr. Osipov has received personal compensation for serving as an employee of Denali Therapeutics. Dr. Osipov has stock in Denali Therapeutics. Dr. Osipov has received intellectual property interests from a discovery or technology relating to health care. 
		
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			Mr. Willman-Yoswa has received personal compensation for serving as an employee of Denali Therapeutics. 
		
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			Mr. Maciuca has received personal compensation for serving as an employee of Denali Therapeutics. Mr. Maciuca has received stock or an ownership interest from Denali Therapeutics. 
		
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			Ms. Dobbins has received personal compensation for serving as an employee of Denali Therapeutics. Ms. Dobbins has stock in Denali Therapeutics. 
		
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			Miss Chau has received personal compensation for serving as an employee of Denali Therapeutics. Miss Chau has stock in Denali Therapeutics. 
		
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			Timothy Earr has nothing to disclose.
		
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			Ms. Nguyen has received personal compensation for serving as an employee of DENALI THERAPEUTICS. Ms. Nguyen has stock in Denali Therapeutics. 
		
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			Mrs. Lopez has nothing to disclose.
		
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			Kimberly Scearce-Levie has received personal compensation for serving as an employee of Denali Therapeutics. Kimberly Scearce-Levie has stock in Denali Therapeutics. 
		
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			Mr. Bunte has nothing to disclose.
		
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			Dr. Van den Berg has nothing to disclose.
		
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			Carole Ho has nothing to disclose.
		
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			Geert-Jan Groeneveld has nothing to disclose.
		
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			Dr. Troyer has received personal compensation for serving as an employee of Denali Therapeutics Inc. Dr. Troyer has stock in Denali Therapeutics Inc. Dr. Troyer has stock in Merck & Co., Inc. Dr. Troyer has stock in Eli Lilly.