This study describes the clinical profile and outcome of chronic kidney disease patients who develop intracerebral hemorrhage.

Stroke rates for ESRD patients are markedly higher than for the general population. Stroke is the third leading cause of cardiovascular disease death among persons with end-stage renal disease on dialysis. The risk of hemorrhagic stroke has been reported to be higher than ischemic stroke in hemodialysis patients. The occurrence of intracerebral hemorrhage in chronic kidney disease patients in the Philippines is yet to be systematically described.

A retrospective study was done in specialized center for kidney disease. It included all patients in 2017 to 2019 with chronic kidney disease patients who developed acute intracerebral hemorrhage. Other vascular events (subdural hemorrhage and subarachnoid hemorrhage) were excluded.

There were 88 patients included. The mean age was 49.7± 12years and females outnumber males at 62.5% vs 37.5%. Majority were CKD stage 5 at the time of stroke. Hypertension and diabetes mellitus were the leading causes of CKD identified and were also the co-morbidities seen in most patients. Majority were on hemodialysis. Platelet counts, prothrombin time and activated partial thromboplastin time were within normal range in most patients and only a few patients were taking anticoagulant or antiplatelet prior to the stroke. Intracerebral hemorrhage was most commonly seen in the basal ganglia/putamen, lobar and in the thalamus and most with an ICH score of 0-2.  Majority had poor neurologic outcomes with an MRS of 4-5 or even death.

This study showed that majority patients with CKD who develop intracerebral hemorrhage had poor outcome. This is consistent with studies done in other countries.