Clinical Outcomes of Older Persons and Persons With Dementia Admitted for Coronavirus Disease 2019: Findings From the Philippine CORONA Study
Michelle Anlacan1, Bernadeth Lyn Piamonte1, Marie Charmaine Sy1, Emilio Villanueva III2, Roland Dominic Jamora1, Adrian Espiritu3
1Department of Neurosciences, 2Department of Pathology, College of Medicine and Philippine General Hospital, University of the Philippines Manila, 3BARLO MS Centre, St. Michael's Hospital, University of Toronto
Objective:
We aimed to describe the clinical features of older persons admitted for coronavirus disease 2019 (COVID-19) and to compare their outcomes with other adults with COVID-19. We also aimed to determine the association between dementia and COVID-19 outcomes.
Background:

The Philippine CORONA Study is a multicenter, retrospective, cohort study of 10,881 COVID-19 admissions between February and December 2020.

Design/Methods:

Subgroup analysis was done on clinical outcomes of mortality, respiratory failure, duration of ventilator dependence (DVD), intensive care unit (ICU) admission, length of ICU stay (LICUS), and length of hospital stay (LHS) among older persons and persons with dementia.

Results:

The adjusted hazard ratios (aHRs) for mortality among the mild and severe cases were significantly higher by 3.93, 95% CI [2.81, 5.50] and by 1.81, 95% CI [1.43, 2.93], respectively, in older persons compared to younger adults. The aHRs for respiratory failure in older persons were increased by 2.65, 95% CI [1.92, 3.68] and by 1.27, 95% CI [1.01, 1.59] among the mild and severe cases, respectively. The aHR for ICU admission in older persons was higher by 1.95, 95% CI [1.47, 2.59] among the mild cases. The aHRs for mortality and ICU admission in persons with dementia were higher by 7.25, 95% CI [2.67, 19.68] and by 4.37, 95% CI [1.08, 17.63], respectively, compared to those without dementia.

Conclusions:

Older age and dementia significantly increased the risk of mortality, respiratory failure, and ICU admission among COVID-19 patients.

10.1212/WNL.0000000000203525