Disability in Migraine: Multicountry Results From the CaMEO-International Study
Zaza Katsarava1, Dawn C. Buse2, Elizabeth Leroux3, Michel Lanteri-Minet4, Fumihiko Sakai5, Manjit Matharu6, Katherine Sommer7, Michael J. Seminerio7, Kristina Fanning8, Richard B. Lipton2
1Evangelical Hospital Unna, 2Albert Einstein College of Medicine, 3Centre Medical Brunswick, 4CHU De Nice, 5Saitama International Headache Center, 6Institute of Neurology, 7AbbVie, 8MIST Research
Objective:
To describe disability among individuals with migraine.
Background:
Although individual studies evaluating headache burden are available from many countries, few studies have been conducted across multiple countries using the same methodology.
Design/Methods:
Chronic Migraine Epidemiology and Outcomes-International (CaMEO-I) was a cross-sectional, web-based survey conducted in 2021-2022 in Canada, France, Germany, Japan, the United Kingdom, and the United States. The American Migraine Study/American Migraine Prevalence and Prevention Study diagnostic questionnaire identified respondents with migraine based on modified International Classification of Headache Disorders, 3rd edition, criteria. This analysis evaluated migraine burden using the Migraine-Specific Quality of Life Questionnaire (MSQ) and the Work Productivity and Activity Impairment Questionnaire (WPAI). The MSQ is a 14-item questionnaire that measures the effect of migraine on daily functioning across 3 domains, with higher scores corresponding to better quality of life. The WPAI evaluates the impact of migraine on work productivity and regular activities.
Results:
This analysis included 14,492 respondents with migraine (~2400 from each country). Mean (SD) MSQ scores ranged from 57.7 (23.4) in Canada to 63.3 (21.1) in France for the role function restrictive domain, 67.6 (22.9) in Germany to 77.3 (22.7) in Japan for the role function preventive domain, and 63.9 (29.1) in the US to 69.2 (24.8) in France for the emotional function domain. Based on the WPAI, the mean (SD) percentage of work missed (absenteeism) ranged from 4.3% (16.2) in France to 9.0% (21.7) in Germany, percentage of work impaired (presenteeism) ranged from 31.2% (28.0) in France to 47.8% (28.6) in Japan, percentage of overall work impaired ranged from 33.5% (30.3) in France to 49.4% (29.4) in Japan, and percentage of activity impaired ranged from 39.3% (30.2) in France to 50.7% (28.4) in Japan.
Conclusions:
For every country surveyed, migraine is associated with substantial burden, including poor quality of life and work/activity impairment.