Fen Xing^{1} and Guangyao Wu^{2}

^{1}RenMin hospital of Wuhan University, Wuhan, China, ^{2}Zhongnan Hospital of Wuhan University, Wuhan, China

### Synopsis

In this study, thirty-six cases of
meningioma were divided into benign and malignant meningioma. ADC values fitted
by 11 b values and any pairs of two b values were used to distinguish between
benign and malignant meningioma. We found that, the ADC values of benign,
malignant, and all meningiomas showed a decreasing trend with the increase of b
value, and the smaller the b value, the greater the decrease. when the b value
was ≥ 200 s/mm^{2},
any combinations of b values could discriminate between benign and malignant
meningioma. The ADC values obtained by fitting b = 700 and b = 1000 s/mm^{2} had
the highest AUC value.

**Purpose**

To evaluate the differential diagnostic value of ADC values fitted with
different b-value combinations in
benign and malignant meningiomas, and to investigate the optimal b value of DWI imaging in differential
diagnosis of meningiomas.**Methods**

Thirty-six cases of meningioma were eventually included in the
experiment. According to the pathological results, they were divided into two
groups: benign and malignant meningioma. ADC values fitted by 11 b values (0, 50, 100, 150, 200, 300,
400, 500, 700, 900, 1000 s/mm^{2}) and any pairs of two b values (56 pairs in total) were used
to distinguish between benign and malignant meningioma. Independent sample
t-test and Mann-Whitney U test were used to evaluate the differential
diagnostic value of ADC values, and receiver operating characteristic (ROC)
curves were used to determine the diagnostic performance, thresholds,
sensitivity, and specificity of ADC values.**Results**

The ADC values of benign, malignant, and all
meningiomas showed a decreasing trend with the increase of b value, and the smaller the b
value, the greater the decrease (as shown in **Table 1** and **Fig.1**). We exclued the sensitivity and specificity of
combinations less than 60%, and found that, when the b value was ≥ 200 s/mm^{2}, any combinations of b values could discriminate between
benign and malignant meningioma (all *P*
values < 0.05, as shown in **Table 2**
and **Table 3**). The ADC values obtained by fitting b = 700 and b = 1000 s/mm^{2}
had the highest AUC value (0.785), and the threshold, sensitivity and
specificity for distinguishing between benign and malignant meningiomas were
0.755×10^{-3} mm^{2}/s, 72.0%, and 72.7%, respectively (as
shown in **Table 3** and **Fig.2**). The
difference between b = 900 s/mm^{2}
and any other b-values (including
200, 300, 400, 500, 700, and 1000 s/mm^{2}) in benign and malignant
meningiomas was statistically significant (*P*
= 0.022, 0.010, 0.015, 0.004, 0.018, and 0.026, respectively, as shown in **Table 3**).**Conclusions**

ADC values of DWI obtained by fitting different combinations of b-values can effectively distinguish
between benign and malignant meningiomas. The ADC values of benign, malignant,
and all meningioma showed a decreasing trend with the increase of b value, and the smaller the b value, the greater the decrease. b = 700 and 1000 s/mm^{2} is
considered to be the most significant b
value.### Acknowledgements

No acknowledgement found.### References

No reference found.