Lu Yu^{1}, Yuwei Jiang^{1}, Yadong Cui^{1}, Chunmei Li^{1}, Kaining Shi^{2}, and Min Chen^{1}

Diffusion-weighted (DW) MR imaging has a great potential in the study of prostate cancer (PCa). We aimed to assess the feasibility and efficacy of intravoxel incoherent motion-kurtosis (IVIM-Kurtosis) model for the differential diagnosis of PCa, benign prostatic hyperplasia and prostatitis (BPH/prostatitis). Thirty-six patients were enrolled and underwent MRI subsequently using in-bore transrectal MR-guided biopsy as the pathological reference. Significant differences were found for D and f values for the differential diagnosis of PCa and BPH/prostatitis, and D median and f median had the highest area under curve. The f, K and D* were correlated with Gleason score (GS) of PCa.

**Introduction**

Diffusion-weighted (DW) MR imaging combined with various mathematical models has been gaining substantial interest as a possible tool to detect PCa. A few studies have demonstrated the potential of parameters of the diffusion and perfusion. However, few reports about intravoxel incoherent motion kurtosis (IVIM-Kurtosis) model have been reported. The goal of this study was to evaluate the feasibility and diagnosis efficiency of IVIM-Kurtosis model for the differential diagnosis of PCa and BPH/prostatitis. What’s more, we used the histogram analysis in this study for comprehensive evaluation of the characteristics of PCa and BPH/prostatitis.

**Methods**

**Results**

**Discussion**

**Conclusion**

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