MRI Quantitative Parameters of Small-Bowel Perfusion for Early Diagnosing and Assessing Activity of Crohn’s Disease: A Preliminary Study
Xianying Zheng1

1Radiology, First Affiliate Hospital of Fujian Medical University, Fuzhou, Fujian, China


The purpose of this present study is to explore the potential of MR small-bowel perfusion, and to achieve more insights in MRE of CD patients. To this end, the changes of microcirculation of CD are investigated by comparing the quantitative parameters of MR perfusion of inflammatory segments with normal ones and the correlation of the former with CDAI and intestinal wall thickness.


To explore the relationship between MRI quantitative parameters such as the volume transfer constant (Ktrans), the reflux constant (Kep) and the extravascular space volume fraction (Ve) and the change of blood perfusion and permeability of Crohn’s Disease (CD), and evaluate the value of small-bowel perfusion for early diagnosing and assessing activity of CD.


48 patients who underwent bowel examination with magnetic resonance enterography (MRE) were recruited. Ktrans, Kep and Ve of normal and terminal small-bowel were collected and compared. According to Crohn’s disease activity index (CDAI), all patients were divided into three groups such as remissive group, mild group and moderate-severe group. The differences of Ktrans, Kep and Ve among the three groups were compared. The correlations between quantitative parameters and CDAI and small-bowel wall thickness were respectively evaluated.


In 48 patients, Ktrans, Kep and Ve of terminal small-bowel were higher significantly than that of normal bowel (P<0.05) with the most remarkable increase in Ve. There were 13 cases of remissive group, 20 cases of mild group and 15 cases of moderate-severe group. Ktrans, Kep and Ve of remissive group were lower than active group (P<0.05). With the progress of CD, Ktrans, Kep and Ve also increased (P=0.000). All quantitative parameters had high positive correlation with CDAI (P<0.05). However, it was not statistically significant in correlation between Ktrans and small-bowel wall thickness(P=0.471).


MRI quantitative parameters of small-bowel perfusion can reflect the change of blood perfusion and permeability of CD, and have a certain value for early diagnosing and assessing activity of CD.


No acknowledgement found.


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a male patient of 43-years-old in remission stage of CD. A-C MRE imaging. D-F Imaging of Ktrans, Kep and Ve. G Imging of concentration curve.

a male patient of 43-years-old in moderate activity stage of CD. A-B T2WI and DWI imaging. C-E Imaging of Ktrans, Kep and Ve of normal small bowel segment. F-H Imging of Ktrans, Kep and Ve of CD segment. I Imging of concentration curve of normal small bowel segment. J Imging of concentration curve of CD segment.

a male patient of 20-years-old in remission stage of CD. A-C Imaging of Ktrans, Kep and Ve of CD segment. D Imging of concentration curve.

a male patient of 22-years-old in mild activity stage of CD. A-C Imaging of Ktrans, Kep and Ve of CD segment. D Imging of concentration curve.

The correlation between Ktrans, Kep and Ve with CDAI scores.

Proc. Intl. Soc. Mag. Reson. Med. 27 (2019)