Lactate Dehydrogenase-to-Absolute Lymphocyte Count Ratio as a Biomarker of Disease Activity in Myasthenia Gravis
Tahreem Sajjad1, Qamar un nisa1, Wajid Jawaid1, Arooba Iqbal1
1Dow university of health sciences
Objective:
This study attempts to determine the association of lactate dehydrogenase to absolute lymphocyte count ratio (LAR score) with Myasthenia Gravis (MG) severity.
Background:
MG is chronic autoimmune disorder with varying severity, and current assessment methods do not provide cost effective, easily obtainable biomarkers that determines disease activity. The LAR score which indicates both muscle damage and immune function, has demonstrated prognostic significance in some systemic diseases but not studied in MG.
Design/Methods:
This case control study included 65 patients with MG and 65 healthy controls. The disease severity was assessed according to Myasthenia Gravis Activities of Daily Living Scale (MG-ADL). Patients with score of 0 to 15 were grouped into mild to moderate disease and with score of 16 to 24 were grouped into severe disease. LAR score was calculated and compared among disease cases and healthy control groups. The multivariate logistic regression analysis of variables was used to determine the contribution of variance in MG disease severity. Receiver operating characteristics (ROC) curve was plotted to assess the role of LAR as risk factor for MG severity. Statistical significance was taken as P < 0.05.
Results:
LAR score was significantly higher in severe disease as compared to mild to moderate disease groups [1.3 (0.4,2) vs 0.25 (0.1,0.42), P=˂ 0.001] and in disease cases than healthy controls [ 0.3 (0.2,1) vs 0.084 (0.05,0.11), P= ˂ 0.001]. Receiver operating characteristic (ROC) curve analysis showed an area under the curve of 0.872 (95% CI: 0.78–0.96, P=0.000). The optimal cutoff value was ≥ 0.9, yielding a sensitivity of 73.9% and a specificity of 88.1%. Multivariate logistic regression analysis showed that higher LAR score is an independent risk factor of disease severity (OR = 0.308, 95% CI: 0.147-0.470, P= ˂ 0.001).
Conclusions:
LAR score can be used as simple and easily accessible potential marker for disease activity of MG.
Generative AI Usage
No, did not use generative AI in the drafting or editing in this abstract.
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