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441 AKT1/ESR1 and AR/PTEN Alterations Define Cancer-Specific Bone Metastasis in Breast and Prostate Cancer

443 Influence of Preoperative Alignment Phenotype and Correctability on Alignment Variability and Outcomes in Robotic-Assisted Total Knee Arthroplasty

444 Aligning Success: Insights from 85,000 CT Scans on Trochlear Groove Positioning with Kinematic Alignment

446 Unsupervised Machine Learning Driven Dynamic Alignment Classification Under Controlled Load In Navigated Total Knee Arthroplasty

450 What Factors Are Associated with Failure to Achieve Substantial Clinical Benefit Following Primary TKA?