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Efficacy and Safety of Tolebrutinib Versus Placebo in Primary Progressive Multiple Sclerosis: Results from the Phase Three PERSEUS Trial

Author:Fox, Robert   Bar-Or, Amit   Vermersch, Patrick   Oreja Guevara, Celia   Traboulsee, Anthony   Giovannoni, Gavin   Syed, Sana   Sun, Furong   Salloum, Naji   Turner, Timothy   Wallstroem, Erik   Reich, Daniel   

Session Name:PL6: Contemporary Clinical Issues Plenary Session  

Topic:Multiple Sclerosis  

Program Number:PL6.003  

Author Institution:Cleveland Clinic, Cleveland, OH  University of Pennsylvania, Philadelphia, PA  University of Lille, Lille, France  Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, Spain  University of British Columbia, Vancouver, BC, Canada  Queen Mary University London, London, United Kingdom  Sanofi , Cambridge, MA  Sanofi, Morristown, NJ  Sanofi, CHILLY-MAZARIN, France  Sanofi, Cambridge, MA  Translational Neuroradiology Section, National Institutes of Health, Bethesda, MD  

Subgroup Analyses of the Phase Three Tolebrutinib in Non-relapsing Secondary Progressive Multiple Sclerosis (nrSPMS) HERCULES Trial

Author:Fox, Robert J.   Bar-Or, Amit   Traboulsee, Anthony   Oreja-Guevara, Celia   Giovannoni, Gavin   Vermersch, Patrick   Syed, Sana   Li, Ye   Vargas, Wendy S.   Turner, Timothy J.   Wallstroem, Erik   Reich, Daniel S.   

Session Name:P7: Multiple Sclerosis: Clinical Trials 1  

Topic:Multiple Sclerosis  

Program Number:P7.004  

Author Institution:Mellen Center for Multiple Sclerosis, Cleveland Clinic, Cleveland, United States, OH  Center for Neuroinflammation and Experimental Therapeutics and Department of Neurology, University of Pennsylvania, Philadelphia, United States, PA  The University of British Columbia, Division of Neurology, Vancouver, Canada, BC, Canada  Departamento de Neurologia, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, Spain  Departamento de Medicina, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain, Spain  Queen Mary University London, Blizard Institute, Barts and The London School of Medicine and Dentistry, London, United Kingdom, United Kingdom  University of Lille, Inserm U1172, CHU Lille, FHU Precise, Lille, France, France  Sanofi, Cambridge, United States, MA  Sanofi, Bridgewater, United States, MA  Translational Neuroradiology Section, National Institutes of Health, Bethesda, United States, MD  

Subgroup Analysis of the Phase Three Tolebrutinib HERCULES Trial: Disability Accumulation Outcomes in North American Participants

Author:Coyle, Patricia   Bar-Or, Amit   Reich, Daniel   Traboulsee, Anthony   Syed, Sana   Li, Ye   Vargas, Wendy   Fox, Robert   

Session Name:P9: Multiple Sclerosis: Clinical Trials 2  

Topic:Multiple Sclerosis  

Program Number:P9.003  

Author Institution:Stony Brook University Renaissance School of Medicine, Stony Brook, NY  University of Pennsylvania, Philadelphia, PA  Translational Neuroradiology Section, National Institutes of Health, Bethesda, MD  University of British Columbia, Vancouver, BC, Canada  Sanofi, Cambridge, MA  Sanofi, Bridgewater, NJ  Cleveland Clinic, Cleveland, OH