Distinguishing MOG-associated Optic Neuritis: Neurological and Imaging Insights
Naman Sahota1, Marko Tien2
1William Carey University College of Osteopathic Medicine, 2Department of Ophthalmology, University of Toronto
Objective:
To identify clinical/radiologic features associated with myelin oligodendrocyte glycoprotein (MOG) antibody positivity in patients with optic disc edema (ODE).
Background:
MOGAD is a recently defined autoimmune central nervous system disorder. Over the last decade, numerous studies have worked on characterizing the clinical and radiological phenotypes of the disease, however, significant overlap with similar demyelinating diseases continues to challenge diagnosis.
Design/Methods:
In this retrospective review, 191 patients over 5 years at a tertiary neuro-ophthalmology center underwent MOG-IgG fixed cell-based assay. Clinical/radiologic data were compared between MOG+ and MOG− patients.
Results:
MOG was the third most common cause of ODE (21/191), after nonarteritic anterior ischemic optic neuropathy (72/191) and idiopathic optic neuritis (30/191). MOG+ patients were younger (43.6 versus 52.5 years; P = .025), more often had bilateral ODE (42.9% versus 17.5%; P = .001), pain with eye movement (73.7% versus 26.9%; P < .001) and headache (50.0% versus 25.7%; P = .034). Baseline visual acuity and fields were similar to MOG− patients. Longitudinally extensive optic nerve enhancement (P < .001), including enhancement of the intraorbital (P = .040), canalicular (P = .009) and prechiasmal (P = .003) segments, was more common in MOG+ patients.
Conclusions:
MOG+ ODE is associated with younger age, bilaterality, pain, headache and optic nerve enhancement.
Disclaimer: Abstracts were not reviewed by Neurology® and do not reflect the views of Neurology® editors or staff.