Trial of Peer Leaders In Neurology Education (TOPLINE): Interim Data Analysis from a Multicenter Randomized Controlled Non-inferiority Trial of Near-peer Teachers in Neurology Simulation
Paulina Henriquez1, Galina Gheihman2, Yara Mikhaeil-Demo3, Salma Elkolaly4, Rose Healy1, Zachary Lazzari5, Rameez Merchant4, Sarah Parauda6, Terry Park6, Sean Thompson5, Nicholas Morris7, Casey Albin8, Daniel Harrison1
1Neurology, Boston Medical Center, 2Neurology, Brigham & Women's Hospital, 3Neurology, Northwestern University, Feinberg School of Medicine, 4Neurology, University of Missouri School of Medicine, 5Neurology, Emory University School of Medicine, 6Neurology, Westchester Medical Center, 7Neurology, University of Maryland Medical Center, 8Neurology, Emory Healthcare
Objective:

To determine if near-peer debriefing results in resident performance outcomes that are non-inferior to those of residents debriefed by experienced faculty educators in a simulated status epilepticus case.

Background:

Limited faculty time is a barrier to implementing simulation training in neurology. Using near-peer facilitators has been proposed as a strategy to mitigate this challenge. However, whether learners debriefed by near-peers have similar outcomes to those debriefed by faculty is a gap in the literature.

Design/Methods:

This is a pre-specified interim data analysis of a multicenter, randomized control trial. Participants were junior neurology residents (adult PGY2 or pediatric PGY3) recruited from four academic centers. Following pre-briefing, residents’ performance was measured on a critical action checklist from a previously reported simulated status epilepticus case (the “pre-test”). Participants were randomized to receive one-on-one debriefing by a near-peer (intervention group) or faculty member (control group) using Debriefing with Good Judgement. Participants engaged in distraction learning before managing a second case of simulated status epilepticus (the “post-test”). The primary outcome was the change in percent of critical actions completed correctly from the pre- to the post-test.

Results:

Sample size calculation yielded a required 46 participants for 80% power to detect non-inferiority with a margin of 10%. After one year of recruitment, 27 junior neurology residents were enrolled. After debriefing, participant performance improved by 6.4% (p=0.011) in the intervention group and by 11.5% (p<0.001) in the control group. The improvement in performance in the intervention group was not non-inferior to the improvement in the control group (difference of the means 5.1%, CI -11.8% - 1.6%).

Conclusions:

Improvement in checklist-based performance fostered by near-peer debriefers was not non-inferior to improvement fostered by faculty debriefers. The interim analysis is likely underpowered to detect non-inferiority; enrollment is ongoing. Our methodology, investigation, and analysis may inform future multicenter randomized control trials in neurology education.

10.1212/WNL.0000000000217521
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