Artificial Intelligence in Stroke Detection Using CT Imaging in Indian Hospitals: A Systematic Review
Andrea Buendia1, Prashasti Upadhyay1, Victoria Loosigian1, Anindita Deb1
1University of Massachusetts School of Medicine
Objective:
NA
Background:

Stroke remains a major cause of morbidity and mortality worldwide, with India ranking fourth in stroke-related deaths, reporting 53.5 deaths per 100,000 people. Despite significant advances in high-income countries, low- and middle-income regions such as India continue to face diagnostic delays and limited imaging access. Artificial intelligence (AI) has shown potential to improve diagnostic speed and accuracy, particularly in low-resource settings where specialist availability and timely interpretation remain barriers to acute stroke management.

Design/Methods:
A systematic review was conducted following PRISMA guidelines to assess AI-based stroke detection research in India. PubMed and Scopus databases were searched through March 2025. Inclusion criteria required original studies involving AI applications for ischemic or hemorrhagic stroke detection using CT imaging and Indian datasets or affiliations. Screening occurred in four phases: title, secondary title, abstract, and full-text review.
Results:

A total of 705 records were identified (PubMed = 23; Scopus = 682). Following screening, 48 studies met inclusion criteria. Most used deep learning models for CT-based detection or segmentation. This includes convolutional neural networks (CNNs), U-Net variants, and hybrid machine learning ensembles. Studies reported high diagnostic accuracy across both ischemic and hemorrhagic stroke detection tasks, with models achieving sensitivities ranging from 90–98% on institutional and public datasets. However, generalizability remains limited due to small sample sizes, heterogeneity in data sources, and lack of multicenter clinical validation.

Conclusions:
AI-assisted CT interpretation holds substantial potential to enhance the accuracy and timeliness of stroke diagnosis. Future research should prioritize large, regionally diverse datasets, real-world clinical validation, and the creation of lightweight, deployable AI models tailored to India’s resource-limited hospital settings.
10.1212/WNL.0000000000217507
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