Online CME Program Demonstrates Differential Pre-education Awareness of Anti-amyloid Therapies in Alzheimer’s Disease Among Neurologists and a Strong Educational Effect Across Topics
Austin Baiardi1, Thomas Finnegan1, Frances McFarland1
1Medscape Education
Objective:
A study was undertaken to evaluate the impact of an online CME-certified program on identifying treatment goals for early stages of AD and patient selection factors for AATs among neurologists.    
Background:
The clinical adoption of anti-amyloid therapies (AATs) require substantial modifications to how Alzheimer's disease (AD) is managed in practice. Since these medication are a recent addition to the therapeutic landscape in AD, neurologists who are currently in practice may not be aware of the practical consideration related to the use of AATs.
Design/Methods:

The online CME activity consisted of a 30-minute video discussion between 1 dementia expert,  1 neuroradiologist, 1 geriatrician, and 1 patient advocate. Educational effect was assessed by comparing responses to four identical questions presented before and directly after exposure to the intervention.  A paired samples t-test assessed the overall average number of correct responses and a McNemar’s test identified significant between pre- and post-differences in question responses. The educational effect size was calculated by Cohen’s d. Data were collected between March 2025 and June 2025.

Results:

Participation in the CME intervention resulted in a large educational effect size among neurologists (n=113; d=.88; p<0.001). Significant (P <.05) pre- vs post-educational improvements were demonstrated on the following: goals of treating early AD; patient selection factors for AATs; contraindications for AATs. Between 64%-72% correctly answered question on goals of treatment and patient selection factors prior to the intervention. Only 22% correctly answered a question on contraindications for AAT use prior to the intervention.  After participating in the intervention, 37% reported an increase in their confidence to speak with patients and families about the benefits and risks of AATs.

Conclusions:
The results indicated that the CME-certified 30-minute video discussion between experts improved the knowledge of neurologists regarding the appropriate use of AATs. Neurologists would benefit from future education that prioritizes contraindications for AATs. 
10.1212/WNL.0000000000217291
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