Trends in Alzheimer’s Disease–related Mortality Among Individuals with Comorbid Lipid Disorders Across the United States from 1999 to 2023: A CDC WONDER Analysis
Mohammad Sameed Safwan1, Sahla Waqas1, Mahnoor Sheikh2, Usma Javed1, Sadia Malik3, Sidra Zahoor4, Aanusha Ghouri5, Gul Ghouri1, Khawaja Muthammir Hassan6
1King Edward Medical University, 2Pak International Medical College, 3Nishtar Medical University, 4Rawalpindi Medical University, 5Anne Arundel Medical Center, 6Baptist Health
Objective:
This study aims to evaluate the trends and demographic differences in AD-related mortality among individuals aged ≥65 years with coexisting lipid disorders in the U.S. from 1999 to 2023.
Background:

Alzheimer's disease is a neurodegenerative disease of the elderly, resulting in impaired memory and cognition. The relationship between disordered lipid metabolism and the development and progression of Alzheimer's disease, as suggested by new evidence, hasn't been thoroughly investigated.

Design/Methods:

Death certificates from the CDC WONDER database were examined from 1999 to 2023 for AD-related mortality (ICD-10: G30) with a comorbid lipid disorder (ICD-10: E78) in adults aged ≥65 years. Age-adjusted mortality rates (AAMRs) per 100,000 persons and annual percent change (APC) were calculated and stratified by year, sex, race/ethnicity, and geographic region. Joinpoint regression analysis identified significant shifts in mortality trends.

Results:

Between 1999 and 2023, 76,569 Alzheimer’s disease–related deaths with comorbid lipid disorders occurred among older adults. The overall AAMR increased from 0.1 in 1999 to 1.61 in 2023. Women had a higher AAMR than men (0.89 vs 0.75). By region, the West had the highest AAMR (1.08), followed by the Midwest (0.86), South (0.81) and Northeast (0.57). By race/ethnicity, White adults had the highest AAMR (0.86), followed by Hispanic (0.84), American Indian/Alaska Native (0.84), Asian/Pacific Islander (0.77) and Black adults (0.72). Nonmetro areas (0.85) exceeded metro areas (0.76). Nearly half of deaths occurred in nursing/long-term care facilities. States like Wyoming (4.58), Vermont (4.01), and North Dakota (2.62) were in the top 95th percentile.

Conclusions:

This study shows that AD-related mortality, complicated by lipid disorders among older U.S. citizens, increased significantly from 1999 to 2023 with the highest AAMRs being observed in White adults, women, and the Western United States. So, targeted public health strategies are urgently needed to prevent and treat lipid abnormalities, to reduce the growing mortality burden of AD-related deaths.

10.1212/WNL.0000000000216814
Disclaimer: Abstracts were not reviewed by Neurology® and do not reflect the views of Neurology® editors or staff.