Objective:

To determine cognitive outcomes in CVT in India.  

Background:

Cerebral Venous Sinus Thrombosis (CVT) causes up to 15-20% of all stroke. In contrast to arterial strokes, CVT has better outcomes. In the International Study of CVT good outcomes (Modified Rankin Scale ≤2) were found in 86.5%. 

Design/Methods:

This single centre observational cohort study was conducted in a tertiary care referral hospital in Western India, Pune from September 2022 to June 2025. Adult patients with imaging proven CVT were included. Cognition was assessed by Montreal Cognitive Assessment (MoCA) at 1 and/or 3 months. 

Results:

A total of 59 CVT patients were studied with 44 (74.6%) males and mean age was 36.7 years. Aetiologies were hyperhomocystienemia (66.1%), alcohol (28.8%), connective tissue disorders (28.8%), smoking (20.3%), anaemia (25.4%), polycythaemia (13.5%), family history of CVT/DVT (11.8%) and OCP usage (11.8%). Intra cranial haemorrhage was present in 54.2%. Mean MoCA at 1 month was 21.7 and MoCA at 3 months was 23.15. Twenty-one patients had consecutive MoCA performed at 1 and 3 months with mean MoCA at 1 month 20.66 and Mean MoCA at 3 months was 22.57. A paired sample t-test revealed a significant difference p =0.03. Higher MoCA scores were found to correlate with higher education status (Pearson’s correlation r=0.67, p value <0.001); but not correlate significantly with lesser duration of hospital stay (r=-0.16, p value 0.25) and number of thrombosed sinuses (r= 0.14, p value 0.29). 

Conclusions: