Artifactual Signal Detection Using Intraoperative Electrocorticographic Devices During Functional Brain Mapping of Brain Tumor
William Tatum1, Adrian Safa1, Filippo Emanuele Colella2, Erik Middlebrooks3, Anteneh Feyissa1, Aafreen Khan1, David Sabsevitz1, Alicia Kissinger-Knox1, Phillip Gauthier1, Dawn Radford1, Anahita Jafari1, Marco Failla Mulone1, Sanjeet Grewal1, Kaisorn Chaichana1, Alfredo Quinones-Hinojosa1, Brin Freund1
1Mayo Clinic, 2Humanitas University, 3mayo clinic
Objective:
To compare the signal detection performance of a customized circular grid and a strip electrode during intraoperative electrocorticography (iECoG) during functional brain mapping (FBM).
Background:
Intraoperative ECoG is commonly used during awake craniotomy to assist with functional brain mapping and guide safe tumor resection. However, variability in electrode design may influence signal quality and sensitivity to stimulation-related artifacts or physiologic responses. High-density circular grids may offer improved spatial coverage and detection capabilities, but comparative data with conventional strip electrodes remain limited.
Design/Methods:
We performed a single center retrospective evaluation of signal detection by recording intraoperative ECoG comparing a 22-channel high-density circular grid and commercial 1 x 6 linear strip. We quantified physiological and nonphysiological measures involving direct electrical stimulation (DES) artifact, afterdischarges (ADs), and epileptiform activity in patients with brain tumors.
Results:
142 patients underwent awake craniotomy with FBM and iECoG. 26 (18.3%) had reoperations with iECoG. A total of 71 patients had iECoG using circular grids, and 71 with linear strips. Maximum and minimum signal amplitudes of DES artifact were higher with the circular grid (p <0.01). The minimum (2.3 vs. 2.8 mA) and maximum (4.9 vs. 6.3 mA) currents required to evoke DES artifact were lower with the circular grid (p < 0.01). Physiological signals represented by ADs were more frequently detected with the circular grid (182 vs. 82, p = 0.004) and involved more electrodes (5.06 vs. 0.95, p < 0.001).
Conclusions:
High-density circular grids had increased sensitivity to physiological and non-physiological signals with lower DES currents required for detection.
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