Assessing the Concordance of CIDP Clinical Diagnosis to the 2010 EFNS/PNS and the 2021 EAN/PNS Diagnostic Criteria in a Cohort of Patients at KU Medical Center: A Pilot Study
Hussien Alkully1, Mamatha Pasnoor1, Mazen Dimachkie1, Natalie Bartnik1, Omar Jawdat2, Constantine Farmakidis1, Matthew Varon1, Mustafa Al-Kharsan3, Long Davalos1
1University of Kansas Medical Center, 2The University of Kansas Medical Center, 3Kansas University Medical Center
Objective:
This study assesses how many CIDP patients at University of Kansas Medical Center (KUMC) meet the 2010 and 2021 criteria and compares their clinical and electrophysiological (EDX) profiles across both.
Background:
Diagnostic criteria for Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) have evolved to improve accuracy and consistency. The most widely used are the 2010 EFNS/PNS and the updated 2021 EAN/PNS guidelines.
Design/Methods:
Following IRB approval, a retrospective review of CIDP cases at KUMC (2019–2024) was conducted using electronic medical records. Data were collected via a REDCap survey including demographics, clinical features, lab results, diagnoses, and EDX studies. Clinical criteria were assessed manually; EDX criteria were calculated using a standardized formula to determine compliance with both guidelines.
Results:
Of 480 flagged records, 55 were reviewed; 25 were excluded due to missing documentation or lack of CIDP diagnosis. Among 30 confirmed cases (mean age 61.1 years; 63.3% male; 80% Caucasian), 73.3% were initially diagnosed with typical CIDP, half by KU neuromuscular specialists. Final diagnosis confirmed typical CIDP in 66.7%, with 33.3% misdiagnosed.
Among confirmed cases, 75% met both 2010 and 2021 criteria. Clinical criteria were met in 80% (2010) and 90% (2021); EDX criteria in 90% (2010) and 85% (2021). Among alternative diagnoses, 10% met 2010 and 20% met 2021 criteria. Notably, 80% of non-CIDP patients met EDX criteria for both, though only one met 2010 clinical criteria and two met 2021.
Conclusions:
Clinical criteria are the key discriminator for accurate CIDP diagnosis, highlighting the need to educate community neurologists to reduce misdiagnosis.
Full review of all 480 cases is planned before the AAN conference to strengthen conclusions.
Disclaimer: Abstracts were not reviewed by Neurology® and do not reflect the views of Neurology® editors or staff.