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Safety and Effectiveness of Fenfluramine for the Treatment of Seizures in Lennox-Gastaut Syndrome: Results From the Final Analysis of an Open-Label Extension Study

Author:Knupp, Kelly   Scheffer, Ingrid   Ceulemans, Berten   Sullivan, Joseph   Nickels, Katherine   Lagae, Lieven   Guerrini, Renzo   Zuberi, Sameer   Nabbout, Rima   Riney, Kate   Lock, Michael   Dai, David   Davis, Ronald   Morita, Diego   Lothe, Amélie   Langlois, Mélanie   Zhang-Roper, Re   

Session Name:P8: Epilepsy/Clinical Neurophysiology (EEG): Anti-seizure Medications: Clinical Trials  

Topic:Epilepsy/Clinical Neurophysiology (EEG)  

Program Number:P8.002  

Author Institution:Children's Hospital Colorado, Aurora, CO  University of Melbourne, Austin Hospital and Royal Children's Hospital, Florey and Murdoch Children’s Research Institutes, Melbourne, Australia  Antwerp University Hospital, Antwerp, Belgium  University of California San Francisco Weill Institute for Neurosciences, Benioff Children’s Hospital, San Francisco, CA  Mayo Clinic, Rochester, MN  Member of the European Reference Network EpiCARE, University of Leuven, Leuven, Belgium  Meyer Children’s Hospital IRCCS, and University of Florence, Florence, Italy  Paediatric Neurosciences Research Group, Royal Hospital for Children, Glasgow, United Kingdom  Member of European Reference Network EpiCARE, Reference Centre for Rare Epilepsies, Necker Enfants Malades Hospital, APHP, U 1163 Institut Imagine, Université Paris Cité, Paris, France  The University of Queensland, St Lucia  Queensland Children's Hospital, South Brisbane, Australia  Independent Statistical Consultant, Haiku, HI  Syneos Health, Morrisville, NC  Neurology and Epilepsy Research Center, Orlando, FL  UCB, Brussels, Belgium  Hospital Ruber Internacional, Madrid, Spain  

Impact of Fenfluramine on Convulsive Seizure Frequency in Dose-Capped Patients With Dravet Syndrome

Author:Nabbout, Rima   Knupp, Kelly   Lagae, Lieven   Cross, J Helen   Sullivan, Joseph   Gil-Nagel, Antonio   Guerrini, Renzo   Strzelczyk, Adam   Langlois, Mélanie   Healy, Patrick   Lothe, Amélie   Scheffer, Ingrid   

Session Name:P8: Epilepsy/Clinical Neurophysiology (EEG): Anti-seizure Medications: Clinical Trials  

Topic:Epilepsy/Clinical Neurophysiology (EEG)  

Program Number:P8.015  

Author Institution:Member of the European Reference Network EpiCARE, Reference Centre for Rare Epilepsies, Hôpital Universitaire Necker-Enfants Malades, APHP, Institut Imagine, Université Paris Cité, Paris, France  University of Colorado, Children's Hospital Colorado, Aurora, CO  Member of the European Reference Network EpiCARE  University of Leuven, Leuven, Belgium  UCL NIHR BRC Great Ormond Street Institute of Child Health, Great Ormond Street Hospital, London, United Kingdom  University of California San Francisco Weill Institute for Neurosciences, Benioff Children’s Hospital, San Francisco, CA  Hospital Ruber Internacional, Madrid, Spain  IRCCS Fondazione Stella Maris, Pisa  Pediatric Neurology and Neurogenetics Unit, Anna Meyer Children’s Hospital, University of Florence, Florence, Italy  Goethe University Frankfurt, Epilepsy Center Frankfurt Rhine-Main & University Hospital Frankfurt, Frankfurt am Main, Germany  UCB, Brussels, Belgium  University of Melbourne, Austin Hospital and Royal Children’s Hospital, Florey and Murdoch Children’s Research Institutes, Melbourne, Australia  

Safety, Tolerability, Pharmacokinetics, and Efficacy of Fenfluramine in Combination With Cannabidiol: Results From a Phase 1 Study