2025 American Academy of Neurology Abstract Website

Hafiz Maaz¹, Syed Haris Ahmed², Muhammad Sohaib³, Muhammad Tayyab Muzaffar Chaychi⁴, Muhammad Ahmed⁵, Haris Kamal⁶
¹Quaid-e-Azam Medical College, Bahawalpur Pakistan, ²Quaid-e-Azam Medical College, Bahawalpur, Pakistan, ³Department of Epidemiology, Rollins Shool of Public Health, Emory University, ⁴Department of Neurology, University of South Florida Morsani College of Medicine, ⁵Medical College of Georgia, Augusta University, ⁶University of Texas At Houston

Objective:

To assess mortality and In-Patient Outcomes in TM patients from 2006 to 2021.

Background:

Studies reporting mortality and in-patient trends in Transverse Myelitis (TM) are inconsistent and the data on race and gender sub-categorization is limited.

Design/Methods:

This is a retrospective analysis of Transverse Myelitis (TM) (N=13848) hospitalizations from 2006 to 2021 using National Inpatient Sample database. We performed survey-weighted logistic and linear regression models to assess the mortality, discharge disposition and length of stay predictors considering variables age, race, gender and comorbidities.

Results:

Out of 131,367,025 patients, 13,848 were admitted for TM. Mean age was 50.48 (95% CI:50.08-50.88), average LOS 9.52 days(95% CI: 9.30 - 9.75) and total mortality was 1.88% among TM patients. In-mortality was 0.79%(95% CI: 0.48% - 1.32%), 1.18% (95% CI: 0.91% - 1.53%) and 2.91% (95% CI: 2.48% - 3.41%) for age groups <30, 31-55, 55< respectively (p<0.05). Total mean cost was $95415.87($92,423.00 - $98,408.74). Logistic regression analysis showed increasing age increased the odds of mortality by 2.8% (OR: 1.028, 95% CI: 1.017 - 1.038, p < 0.001). Teaching hospital status increased (p=0.003), while older age and longer LOS decreased (p<0.001), the odds of home discharge. Elixhauser comorbidity scores raised in hospital mortality odds by 27.8% per unit increase (OR: 1.278, 95% CI: 1.205 - 1.356, p < 0.001). Regression for LOS showed each year of age decreased LOS by 0.07 days (95% CI: -0.0840 to -0.0553, p<0.001). Racial disparities in LOS were observed: White patients had a mean LOS of 8.81 days (95% CI: 8.55 - 9.06), while Black (10.38 days, 95% CI: 9.83 - 10.94, p=0.008), Hispanic (10.75 days, 95% CI: 9.89 - 11.62, p<0.001), Asian/Pacific Islander (10.94 days, 95% CI: 9.56 - 12.32, p=0.025), and Other race (11.26 days, p=0.046).

Conclusions:

TM hospitalizations are associated with high costs, extended LOS, and increased mortality risk with age and comorbidities, underscoring the need for targeted interventions to improve outcomes.