Objective:

 The purpose of the research was to find common clinical features and ascertain whether surgical outcomes differed for individuals who had resection or not.

Background:

Diffuse large B-cell lymphoma (DLBCL) is the most common presentation of primary central nervous system lymphoma (PCNSL), a relatively uncommon and aggressive brain tumor. Its overall incidence is 0.1-0.5 per 100,000 people per year. Numerous researchers have examined PCNSL's treatment options and prognostic factors in recent years; however, there are still disagreements, and the disease's low incidence and the difficulty of large-scale clinical trials make finding the best course of treatment for it extremely difficult.

Design/Methods:

Data were extracted from the Surveillance, Epidemiology, and End Results (SEER) database for PCNSL patients diagnosed from 2000 to 2021. Patients were grouped according to their clinical characteristics, histological features, and treatments received. We excluded patients with unknown vital status. SPSS version 27 was used for data analysis. The overall survival (OS) differences between patients were investigated using Kaplan-Meier curves and a log-rank test. Mortality prognostic variables were identified using univariate and multivariate analysis.

Results:

A total of 3804 cases of B-cell lymphoma who received chemotherapy were included in our study. 2236 (58.8%) without surgical interventions, and 1568 (41.2%) underwent surgery. Surgical resection showed a higher 5-year over-all survival (OS) and cause-specific survival (CSS) than no surgery (OS: 47.9%, 39.3%, p = 0.01) (CSS: 0.01). Overall survival significantly decreased with the elderly (p 0.001).. Favorable survival was noted in females in comparison to males (p = 0.017). Neither the race nor the location of the primary tumor nor its grade affected the survival, as it doesn’t significantly increase the overall survival months.

Conclusions:

 Surgical interventions still provide additional survival outcomes when combined with chemotherapy. Age and gender play an important role in disease prognostics