Electronic Assessment of Quality of Life in Glioma Patients Using the EORTC-QLQ-C30/ EORTC-BN20 and the PROMIS System in Clinical Practice
Tobias Walbert1, Lonni Schultz2, James M. Snyder3, D. Josh Mohn4
1Neurosurgery and Neurology, Henry Ford Hospital Detroit, 2Henry Ford Hospital, 3Neurosurgery and Neurology, 4Neurology, Henry Ford Health System
Objective:

We aim to assess feasibility of computer adaptations of the Patient-Reported Outcomes Measurement Information System (PROMIS) questionnaire in the clinical setting and compare it with outcomes of the EORTC- QLQ-C30 and EORTC-BN20 questionnaires. 

Background:
Glioblastoma (GBM) is the most aggressive malignant primary brain tumor causing high levels of distress and morbidity. Electronic assessment of quality of life (HRQoL) with standardized methods is of importance. 
Design/Methods:

Newly diagnosed patients with GBM were enrolled to assess feasibility. The PROMIS modules were selected to reflect the HRQoL domains assessed in the EORTC- QLQ-C30 and EORTC-BN20 questionnaires. PROMIS modules selected included anxiety, depression, fatigue, physical function, sleep disturbance, sleep-related impairment, social satisfaction role, applied cognitive ability and global health.

 

Results:

31 patients completed the survey prior to or within 14 days of start of radiation, 12 patients completed a survey outside of the radiation window, and a total of 60 completed surveys were obtained between both patient groups. Descriptive analysis was performed.   The median times to complete the EORTC-QLQ-C30 and the EORTC-BN20 surveys were 4.77 (range=2.05-18.6) and 2.63 (range=1.17- 24.83) minutes respectively.  For the PROMIS instruments except global health, the median times to complete different modules ranged from 0.6- 1 minute (range= 0.15-7.77).  For global health, the median time was 2.35 minutes (range= 1.02-21.12). Average time to complete all PROMIS questions was 8.65 minutes (range=3.32-66.01). 

 

Conclusions:
Real-time prospective assessment without integration into the clinic work-flow is a limiting factor of the PROMIS/EORTC. Online assessment from home was challenging for patients with less social support, low computer literacy and the burden of disease also limits quantity of responses. Electronic assessment of QoL is preferred, but not all patients were able to participate. 
10.1212/WNL.0000000000212690
Disclaimer: Abstracts were not reviewed by Neurology® and do not reflect the views of Neurology® editors or staff.