2025 American Academy of Neurology Abstract Website

Maria Antonia Machado Pereira¹, Izabely Dos reis de paula¹, Hilaria Faria², Marcelo Sousa³, Ocilio Goncalves⁴, Vitor Ribeiro⁴, Vitoria Pinheiro⁵, Pedro Borges⁶, Elizabet Taylor Weba⁷, Breno Alencar⁸, Marcio Ferreira⁹, Venkateshwaran Vijayanarasimhan¹⁰, Sanjeet Grewal¹¹, Denise Maria Cury¹², Gustavo Noleto¹³
¹State University of Piauí, ²Federal University of Santa Maria, ³Federal University of Rio de Janeiro, ⁴Federal University of Piauí, ⁵Ninth of July University, ⁶Neuroscience, D'Or Institute for Research and Education, ⁷State University of Região Tocantina do Maranhão, ⁸Zarns University, ⁹Neurosurgery, Lenox Hill Hospital/Northwell, ¹⁰Neurosurgery, Mayo Clinic, ¹¹Mayo Clinic, ¹²Federal University of Minas Gerais, ¹³University of São Paulo

Objective:

We aim to conduct a systematic review and meta-analysis to assess the postoperative effects of Subthalamic Deep Brain Stimulation (STN-DBS) on sleep quality in patients with Parkinson’s Disease (PD)

Background:

STN-DBS is an effective adjunctive therapy for managing motor symptoms in PD. However, its effect on sleep disturbances is not widely understood.

Design/Methods:

Pubmed, Embase, Scopus, and Web of Science were searched for randomized and non-randomized studies enrolling patients with PD who received DBS surgery. The outcomes of interest were the mean changes between the pre- and post-operative values of the Parkinson's Disease Sleep Scale (PDSS), REM sleep, total sleep time, sleep efficiency, Epworth Sleepiness Scale (ESS), and Wakefulness After Sleep Onset (WASO). Mean differences (MD) with 95% confidence intervals (CI) with a random effects model were used. The statistical analyses were performed using the software R Studio version 4.4.2.

Results:

Twenty-three studies were included in this meta-analysis, comprising 799 patients who underwent DBS. Follow-up ranged between 3 to 52 months. There was no significant difference between pre- and post-operative time in REM sleep (MD 13.32; CI -2.19 to 28.82; p = 0.09), ESS (MD -1.35; 95% CI -2.93 to 0.22; p = 0.09), total sleep time (MD 24.99; 95% CI: -14.74 to 64.73; p = 0.22), sleep efficiency (MD 3.85; 95% CI -4.40 to 12.10; p = 0.36), WASO (MD -35.87; 95% CI -79.59 to 7.84; p = 0.11). However, PDSS (MD 17.09; 95% CI: 12.31 to 21.86; p < 0.01) was significantly higher postoperatively compared to the preoperative period in these patients.

Conclusions:

This meta-analysis reveals that DBS has a limited impact on overall sleep outcomes in PD patients.