Disparities in Stroke-Related Mortality Among Individuals with Obesity Based on Race and Gender in the United States from 1999 to 2020: An Analysis from the DC-WONDER Database.
Muhammad Ahmed1, Zain Nadeem2, Muhammad Sohaib3, Muhammad Tayyab Muzaffar Chaychi4, Hafiz Maaz5
1Medical College of Georgia, Augusta University, 2Allama Iqbal Medical College, 3Emory University Rollin School of public health, 4Usf, 5Quaid-e-Azam Medical College, Bahawalpur Pakistan
Objective:
This study aims to elucidate the trends in stroke-related mortality among obese patients in the US over two decades, stratified by race and gender.
Background:

Obesity has been recognized as an important risk factor for cardiovascular and cerebrovascular diseases. However, exact data about the mortality trends is not available.

Design/Methods:
Data from the CDC-WONDER database was analyzed from 1999 to 2020 to assess stroke-related mortality rates among individuals with obesity. Crude mortality rates (CMRs) and age-adjusted mortality rates (AAMRs) were calculated, and trends were analyzed using Joinpoint regression to identify changes in mortality patterns over time by determining the annual per cent change (APC) in rates. The analysis was stratified by race and gender.
Results:

From 1999 to 2020, a total of 9368 deaths occurred due to stroke in individuals with obesity. AAMRs increased moderately till 2018 (APC: 2.94) and sharply thereafter till 2020 (APC: 18.96).  AAMR was higher in females (0.22) than males (0.19), but males showed a greater increase in AAMR from 1999 to 2020. Non-Hispanic (NH) Blacks or African Americans displayed the highest AAMR (0.40) while NH Asians or Pacific Islanders displayed the lowest (0.08). AAMRs also varied substantially by region (West: 0.23; Midwest: 0.21; South: 0.20; Northeast: 0.12). Rural regions exhibited a higher AAMR (0.27) than Urban regions (0.20). CMRs increased consistently for all age groups from 1999 to 2020, except those aged 85+ years who showed a stable trend till 2018 and a sudden sharp increase thereafter till 2020.

Conclusions:
The overall stroke-related obesity in obese individuals has increased over the years. Significant disparities exist between genders and Black or African American and Hispanic populations.
10.1212/WNL.0000000000212270
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