Local Field Potential Circadian Patterns During Adaptive Deep Brain Stimulation
Coralie De Hemptinne1, Todd Herrington2, Martijn Beudel3, Jill Ostrem4, Simon Little4, Leonardo Almeida5, Adolfo Ramirez Zamora6, Alfonso Fasano7, Travis Hassell8, Kyle Mitchell9, Elena Moro10, Michal Gostkowski11, Nagaraja Sarangmat12, Scott Stanslaski13, Lisa Tonder13, Ye Tan13, Nathan Morelli13, Rebekah Summers13, Helen Bronte-Stewart14
1University of Florida, 2Massachusetts General Hospital, 3Amsterdam University Medical Centers, 4UCSF, 5University of Minnesota, 6Fixel Neurological Institute, 7Toronto Western Hospital - U of Toronto, 8Vanderbilt University Medical Center, 9Duke University Movement Disorders Center, 10Grenoble Alpes University, 11Cleveland Clinic, 12Oxford University Hospital NHS foundation trust, 13Medtronic, 14Stanford Neurology
Objective:
Characterize circadian patterns of neural activity from basal ganglia nuclei in a naturalistic environment during adaptive deep brain stimulation (aDBS) in people with Parkinson’s disease (PD).
Background:
Chronic recordings of local field potentials (LFP) from basal ganglia nuclei can be utilized as a control signal for aDBS, and these recordings have revealed circadian patterns of neural activity. However, the impact of aDBS algorithms on circadian fluctuations is unknown.
Design/Methods:
The ADAPT-PD Trial (NCT04547712) is an international, multicenter, prospective, single-blind, randomized crossover pivotal trial of chronic aDBS in people with PD. Alpha-beta (8-30Hz) power was recorded during single threshold aDBS (ST-aDBS) and dual threshold aDBS (DT-aDBS). The median LFP power was derived for daytime (09:00-18:00) and nighttime (23:00-06:00) epochs.
Results:
A total of 85 people with PD (age: 61.8[8.0]; sex: 61-males, disease duration: 12.4[6.6]) were enrolled in the study. The median [IQR] threshold (bits) used for ST-aDBS was 1182[563-2119] for ST-aDBS (N=72 hemispheres), 662[383-1275] for the upper threshold and 385[187-682] for the lower threshold in DT-aDBS (N=101 hemispheres). The median stimulation amplitude was 2.2 for ST-aDBS and 2.4 for DT-aDBS. Median daytime LFP power was 973[554-2032] for ST-aDBS, and 531[276-1095] for DT-aDBS. Median nighttime LFP power was 613[384-1231] for ST-aDBS, and 304[173-624] for DT-aDBS. LFP power change from day to night was -258[-660- -70] for ST-aDBS, and -178[-479- -30] for DT-aDBS.
Conclusions:
Alpha-beta power demonstrated circadian patterns during aDBS in people with PD. Clinical data and statistical comparisons between aDBS modes will be featured at the time of presentation.
Disclaimer: Abstracts were not reviewed by Neurology® and do not reflect the views of Neurology® editors or staff.