Intermittent Calorie Restriction for Relapsing-remitting Multiple Sclerosis- A Systematic Review and Meta-analysis
Laura Finn1, Lucas Kotecki2, Fátima Leite3, Felipe Gouhie4, Pedro Grossi1, Anna Vasconcelos5
1Universidade de Caxias do Sul, 2Centro Universitário de Várzea Grande, 3Universidade Federal de Minas Gerais, 4Universidade Federal de Uberlândia, 5Afya Faculdade de Ciências Médicas de Santa Inês
Objective:
We aimed to perform a meta-analysis of metabolic endpoints from studies comparing intermittent calorie restriction (iCR) with a regular diet for patients with relapsing-remitting multiple sclerosis (RRMS).
Background:
ICR is a diet therapy that has been studied for treatment of RRMS. Understanding the effects of iCR in metabolic parameters is critical considering the long treatment durations associated with multiple sclerosis.
Design/Methods:
We searched Pubmed, Embase and Cochrane Central for studies comparing iCR to an unrestricted diet in patients with RRMS treated with disease-modifying therapy (DMT). Primary outcomes were serum leptin and adiponectin levels. Statistical analysis was performed using R Studio 4.3.1. Heterogeneity was assessed with I² statistics.
Results:
In our analysis, 1,150 articles were identified, of which we included three studies, comprising a total of 66 patients, of which iCR was the treatment option in 34 (51.51%) patients. Leptin (SMD 0.06; 95% CI [-1.34;1.47]; p=0.93; I²=86%) and adiponectin (SMD 1.35; 95% CI [-2.58; 5.29]; p=0.50; I²=92%) both had no clinical difference between the intervention and the control group.
Conclusions:
We cannot definitively ascertain the impact of iCR on adiponectin and leptin levels among RRMS patients. Further research is warranted to provide a clearer understanding of this intervention's metabolic effect.
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