Association Between Hyperlipidemia of the US population and Cerebrovascular Diseases (CVD) Mortality from 1999 to 2020.
Tabia Shujaat1, Kalpina Kumar1, Javeria Javeid2, Dinesh Kumar1, Aidan Keaveny3, Madelyn Ross3, Syed Inam4
1Dow University of Health Sciences, 2Allama Iqbal Medical College, 3Marshall University Joan C Edwards School of Medicine, 4Marshall Neurology
Objective:
To determine the mortality trends and disparities in hyperlipidemia-related cerebrovascular diseases (CVD) among older adults in the United States.
Background:
Hyperlipidemia is a modifiable risk factor, affecting approximately 60-70% individuals with CVD, yet the trends and disparities in hyperlipidemia-related CVD remain overlooked.
Design/Methods:

Using the CDC WONDER multiple cause of death database, hyperlipidemia-related CVD mortality among older adults (65+ years) was examined from 1999-2020. Age-Adjusted Mortality Rates (AAMRs) per 100,000 individuals were calculated. Annual Percentage Change (APC) and trends were analyzed across demographic (gender, race/ethnicity) and regional groups using Joinpoint regression.


Results:

Between 1999 and 2020, 123,318 older adults suffered from hyperlipidemia-related CVD deaths in the US. Overall, The AAMR for mortality increased from 5.27 in 1999 and 20.9 in 2020, ascending from 1999 to 2004 (APC: 14.7 [12.3 to 18.6]). Following  a slower rise from 2004 to 2010 (APC: 5.7% [4.1 to 7.6]), the rates stabilized till 2018, with a significant rise from 2018 to 2020 (APC: 13.9 [9.9 to 16.8]) with an average annual percentage decrease of 6.6% (6.3 to 7.1). Males showed higher AAMR than females (14.45 vs 12.63). Non-Hispanic (NH) Blacks had the highest AAMR (14.44), followed by NH Whites (13.49), NH Asians (12.99), and Hispanics (10.78). Regionally, West had the highest AAMR (15.7) and Northeast the lowest (11.4). Additionally, non-metropolitan surpassed metropolitan areas, Vermont showing the highest AAMR (34.98) and Nevada the lowest (6.46).


Conclusions:

These findings highlight significant differences in hyperlipidemia-related CVD deaths among older adults from 1999 to 2020, with males, NH Blacks, the western region and non-metropolitan areas being the most affected. This underscores the critical need to combat stroke mortality associated with hyperlipidemia by implementing targeted interventions, especially among high-risk groups.


10.1212/WNL.0000000000211776
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