2025 American Academy of Neurology Abstract Website

Dinesh Kumar¹, Kalpina Kumar¹, Tabia Shujaat¹, Javeria Javeid², Wajeeh Hassan², Kabeer Nangdev³, Muhammad Inam Ul Haq⁴, Aidan Keaveny⁵, Syed Inam⁶, Lauren Fife⁵
¹Dow University of Health Sciences, ²Allama Iqbal Medical College, ³Chandka Medical College, Shaheed Mohtrama Benazir Bhutto Medical University, ⁴Marshall University Neurology, ⁵Marshall University Joan C Edwards School of Medicine, ⁶Marshall Neurology

Objective:

To investigate mortality trends among adults with sleep disorders in the United States from 1999 to 2020.

Background:

Sleep disorders are associated with 3.4%-8.4% mortality in the United States, primarily in adults. However, demographic and regional disparities in mortality trends are still unexplored.

Design/Methods:

CDC WONDER death certificate data (1999-2020) was obtained to identify national trends in sleep disorder-related mortality among adults (45+ years). Age-adjusted mortality Rates (AAMRs) per 100,000 individuals were calculated and further categorized by sex, race/ethnicity, urban/rural setting, and geographic location. Joinpoint regression software was used to examine the trend and Annual Percentage Change (APCs).

Results:

A total of 221,213 deaths were reported in adults with sleep disorders. Overall, the AAMR increased from 2.57 in 1999 to 16.85 in 2020. The trend increased from 1999 to 2006 [APC, 12.9% (10.9-16.3)]. Following a steady rise until 2018 [APC, 6.2% (4.7-6.7)], with a substantial increase till 2020 [APC, 14.4% (8.9-17.2)]. Males had a higher AAMR (8.41) than females (5.86). Non-Hispanic (NH) Blacks had the highest AAMR (9.82), followed by NH American Indian (9.07), NH Whites (8.87), Hispanics (4.98), and NH Asians (2.29). Regionally, the Midwest had the highest AAMR (10.23), with non-metropolitan areas showing a higher AAMR (9.87) than metropolitan cities (8.14). Additionally, Montana had the highest AAMR (15.16) while New York the lowest (3.84).

Conclusions:

A notable rise in sleep disorders-related mortality among adults between 1999 and 2020, with males, NH Blacks, the Midwest and non-metropolitan areas being the most affected. These findings underscore the urgent need for targeted interventions and making early recognition critical to appropriate management and improved health outcomes.