2025 American Academy of Neurology Abstract Website

Objective:

To evaluate the feasibility of a computerized cognitive testing battery called Creyos in people with epilepsy (PwE) for comparison to status epilepticus (SE) survivors longitudinally.

Background:

Cognitive impairments have been described as an essential comorbidity of epilepsy. Despite the importance of routine cognitive testing in PwE or the potential use of cognitive tests for triaging patients to resource-intensive neuropsychological evaluations, the validity of cognitive tests for PwE remains understudied. Impaired cognition after SE is commonly reported but is even less understood. Cognitive prognosis for SE survivors is also limited by inconsistent or minimal investigation into clinical factors that are associated with impaired cognition.

Design/Methods:

Adult PwE were recruited from the Epilepsy Monitoring Unit and SE survivors were recruited from two Intensive Care Units in London, Ontario, Canada. Using an iPad, participants completed the Creyos battery which involves 12 tasks evaluating various cognitive abilities. PwE completed the battery once and SE survivors complete the battery five times over one year (SE data collection is ongoing). Participants’ scores were compared to age- and sex-matched norms from the Creyos database.

Results:

PwE (N = 45) performed worse than matched norms on 11 tasks (p < .01) and in the three domains that the 12 tasks map onto: short-term memory (t = -5.19), reasoning (t = -3.17), and verbal processing (t = -7.53). There were no relationships between PwE’s Creyos performance and clinical factors (for example, epilepsy duration, generalized versus temporal lobe epilepsy). The most up-to-date data, including longitudinal results from SE survivors, will be presented.

Conclusions:

Creyos is feasible for PwE and illustrated the widespread cognitive impairment among PwE. This data will be compared to SE survivors’ Creyos performance longitudinally during the recovery trajectory to evaluate cognitive recovery from SE and the relationship between seizure severity and cognition.