Efficacy and Safety of IPX203 in Parkinson's Patients: A Systematic Review and Meta-analysis
Asmaa Zakria Alnajjar1, Maha AbuZarifa2, Khaled A. Zakout2, Younis Alemour3, Moaz Elsayed Abouelmagd4, Siham Alshawamreh5, Mostafa Meshref6, Tayef Aldirawi5
1Faculty of Medicine, Al-Azhar University, Gaza, Palestine., 2Al-Quds University, Al-Azhar Branch, Gaza, Palestine., 3Faculty of Medicine, Al-Quds University, Al-Azhar Branch, Gaza, Palestine, 4Faculty of Medicine, Cairo University, Cairo, Egypt., 5Faculty of Medicine, Al-Quds University- Al-Azhar branch, Gaza, Palestine, 6Al-Azhar University, Cairo
Objective:
 This study aims to compare IPX203 with immediate-release (IR) CD-LD formulations, focusing on its effects in reducing "off" time, increasing "good on" time, and improving overall motor function, while assessing the associated adverse events.
Background:

Parkinson's disease (PD) is one of the most common neurodegenerative disorders, characterized by motor symptoms in addition to non-motor symptoms that significantly impact the quality of life. While levodopa remains the gold standard for PD treatment, chronic use is associated with motor complications, including the "wearing-off" phenomenon and dyskinesia. IPX203, a novel extended-release carbidopa-levodopa (CD-LD) formulation, combines immediate-release granules with extended-release effects to maintain therapeutic plasma levels longer, potentially improving motor symptom management for PD patients.

Design/Methods:

A computer literature search of PubMed, Scopus, Web of Science, Google Scholar, and Cochrane Library was conducted using relevant keywords. Records were screened for eligible studies and data were extracted and synthesized using Review Manager version 4.5 for Windows. 

Results:

Four RCTs with a total of 712 patients were eligible for the final analysis.  The mean difference (MD) of change in the main outcomes from baseline to endpoint favored IPX203 over IR CD-LD (UPDRS) (MD = -6.80, 95% CI: [-9.38, -4.23]; p < 0.00001).  change in the off time favored IPX203 over IR CD-LD after sensitivity analysis (MD = -2.42, 95% CI: [-3.12, -1.71]; P < 0.00001). The mean difference (MD) of change in the “ good on”  time  favored IPX203 over IR CD-LD after sensitivity analysis  (MD = 2.15, 95% CI: [1.45, 2.86]; P < 0.00001). None of the adverse events were significantly higher in the case of IPX203 compared to IR CD-LD.

Conclusions:
IPX203 shows a significant potential in improving motor functions, reducing “off” time while increasing “good on” time. This makes IPX203 a valuable addition to current PD treatment strategies. 
10.1212/WNL.0000000000208983
Disclaimer: Abstracts were not reviewed by Neurology® and do not reflect the views of Neurology® editors or staff.