2025 American Academy of Neurology Abstract Website

Muhammad Sohaib Khan¹, Wania Moeen¹, Muzamil Khan², Mohammad Danish¹, Umar Mahmood¹, Maheen Hashmi¹, Aliyan Nadeem¹, Sakshi Roy³, Arun Subash¹, Muhammad Jansher¹, Maryam Zaroo⁴, Minaam Farooq⁵
¹DOW University of Health Sciences, ²The George Washington University School of Medicine and Health Sciences, ³School of Medicine, Queen’s University Belfast, ⁴Government Medical College, Anantnag, ⁵King Edward Medical University, Mayo Hospital

Objective:

Our study aims to assess Intracerebral Hemorrhage-related mortality trends in the United States from 1999 to 2020.

Background:

Intracerebral Hemorrhage (ICH) constitutes 10-15% of all stroke cases associating it with significant disability and mortality. However, ICH-related mortality trends remain poorly understood.

Design/Methods:

We utilized death certificate data from the CDC-WONDER (Centers for Disease Control and Prevention Wide-Ranging OnLine Data for Epidemiologic Research) database to examine ICH-related mortality trends from 1999 to 2020. We calculated Age-Adjusted Mortality Rates (AAMRs) per 100,000 persons. Additionally, we calculated the Annual Percentage Change (APC) for each category using the Joinpoint Regression software.

Results:

Between 1999 and 2020, there were 546,248 ICH-related deaths. The AAMR decreased from 10.1 in 1999 to 6.6 in 2012 (APC: -3.48; 95% CI: -3.73 to -3.28). From 2012 onwards, the AAMR very slightly declined to 6.5 in 2020 (APC: -0.04; 95% CI: -0.59 to -0.69). Males had higher AAMRs than females from 1999 (AAMR males: 11.2 vs. females: 9.1) to 2020 (AAMR males: 7.5 vs. females: 5.6) and older adults (75 and above) had higher mortality rates than younger groups throughout the study period. Non-Hispanic African American adults had the highest AAMR (10.5), while Hispanic adults had the lowest (6.7). AAMRs also differed by census region (highest: South 8.0 and lowest: Northeast 6.8), and by urbanization level (AAMR: Non-metropolitan areas 8.1; Metropolitan areas 7.4).

Conclusions:

Following a decline from 1999 to 2012, ICH-related mortality in individuals in the US has almost plateaued. Males, African-Americans, older adults, non-metropolitan areas, and the southern U.S areas have the highest AAMRs, indicating targeted interventions in these populations.