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Classical Pathway Inhibition with Anti-active C1s Antibody DNTH103 Prevents Neurotransmission Impairment in a Preclinical Model of Myasthenia Gravis

Author:Gokhale, Sankalp   Narayanaswami, Pushpa   Vu, Tuan   Vissing, John   Peric, Stojan   Vadysirisack, Douangsone   

Session Name:S15: Autoimmune Neuromuscular Diseases: New Observations and Therapeutic Approaches  

Topic:Neuromuscular and Clinical Neurophysiology (EMG)  

Program Number:S15.001  

Author Institution:Dianthus Therapeutics, New York, NY  Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA  University of South Florida Health Morsani College of Medicine, Tampa, FL  University of Copenhagen, Copenhagen, Denmark  University of Belgrade, Belgrade, Serbia  

Long-term Safety and Efficacy of Zilucoplan in Myasthenia Gravis: Additional Interim Analyses of RAISE-XT

Author:Howard, James F.   Freimer, Miriam   Genge, Angela   Hewamadduma, Channa   Hussain, Yessar   Maniaol, Angelina   Mantegazza, Renato   Smilowski, Marek   Utsugisawa, Kimiaki   Vu, Tuan   Weiss, Michael   Duda, Petra   Boroojerdi, Babak   Vanderkelen, Mark   De La Borderie, Guillemette   Leite, M. Isabel   

Session Name:S15: Autoimmune Neuromuscular Diseases: New Observations and Therapeutic Approaches  

Topic:Neuromuscular and Clinical Neurophysiology (EMG)  

Program Number:S15.002  

Author Institution:Department of Neurology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, Chapel Hill, NC  Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH, USA, Columbus, OH  Clinical Research Unit, The Montreal Neurological Institute, Montreal, QC, Canada, Montreal, QC, Canada  Academic Neuroscience Unit, Sheffield Teaching Hospitals Foundation Trust, Sheffield, UK  Sheffield Institute for Translational Neurosciences (SITRAN), University of Sheffield, Sheffield, UK, Sheffield, United Kingdom  Department of Neurology, Dell Medical School, The University of Texas at Austin, Austin, TX, USA, Austin, TX  Department of Neurology, Oslo University Hospital, Oslo, Norway, Oslo, Norway  Department of Neuroimmunology and Neuromuscular Diseases, Fondazione IRCCS, Istituto Nazionale Neurologico Carlo Besta, Milan, Italy, Milan, Italy  Medical University of Silesia, Katowice, Poland, KATOWICE, Poland  Department of Neurology, Hanamaki General Hospital, Hanamaki, Japan, Hanamaki, Japan  Department of Neurology, University of South Florida Morsani College of Medicine, Tampa, FL, USA, Tampa, FL  Department of Neurology, University of Washington Medical Center, Seattle, WA, USA, Seattle, WA  UCB Pharma, Cambridge, MA, USA, Cambridge, MA  UCB Pharma, Monheim, Germany, Monheim, Germany  UCB Pharma, Braine-l’Alleud, Belgium, Braine L'Alleud, Belgium  UCB Pharma, Brussels, Belgium, Brussels, Belgium  Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK , Oxford, United Kingdom  

Long-term Efficacy and Safety of Ravulizumab, a Long-acting Terminal Complement Inhibitor, in Adults with Anti-acetylcholine Receptor Antibody-positive Generalized Myasthenia Gravis: Final Results from the Phase 3 CHAMPION MG Open-label Extension

Author:Vu, Tuan   Mantegazza, Renato   Annane, Djillali   Katsuno, Masahisa   Meisel, Andreas   Nicolle, Michael   Bril, Vera   Aguzzi, Rasha   Frick, Glen   Howard, James   

Session Name:S15: Autoimmune Neuromuscular Diseases: New Observations and Therapeutic Approaches  

Topic:Neuromuscular and Clinical Neurophysiology (EMG)  

Program Number:S15.010  

Author Institution:University of South Florida Morsani College of Medicine, Tampa, FL  Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy  Hôpital Raymond Poincaré, Garches, France  Nagoya University Graduate School of Medicine, Nagoya, Japan  Charité Universitätsmedizin Berlin, Berlin, Germany  London Health Sciences Centre, London, ON, Canada  University of Toronto, Toronto, ON, Canada  Alexion, AstraZeneca Rare Disease, Boston, MA  The University of North Carolina, Chapel Hill, NC  

Clinically Meaningful Improvement in Physical Fatigue and Muscle Weakness Fatigability with Rozanolixizumab: Post-hoc Analysis of MG Symptoms PRO Responder Rate in the MycarinG study

Author:Habib, Ali A.   Kaminski, Henry J.   Grosskreutz, Julian   Mantegazza, Renato   Vu, Tuan   Vissing, John   Boehnlein, Marion   Greve, Bernhard   Grimson, Fiona   Hareendran, Asha   Bril, Vera   

Session Name:P4: Neuromuscular and Clinical Neurophysiology (EMG): Myasthenia Gravis 1  

Topic:Neuromuscular and Clinical Neurophysiology (EMG)  

Program Number:P4.001  

Author Institution:MDA ALS and Neuromuscular Center, University of California, Irvine, Irvine, CA, USA, Orange, CA  Department of Neurology & Rehabilitation Medicine, George Washington University, Washington, DC, USA, Washington, DC  Precision Neurology, Department of Neurology, University of Lübeck, Lübeck, Germany, Lübeck, Germany  Department of Neuroimmunology and Neuromuscular Diseases, Fondazione IRCCS, Istituto Nazionale Neurologico Carlo Besta, Milan, Italy, Milan, Italy  Department of Neurology, University of South Florida Morsani College of Medicine, Tampa, FL, USA, Tampa, FL  Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark, Copenhagen, Denmark  UCB Pharma, Monheim, Germany, Monheim, Germany  UCB Pharma, Slough, UK, London, United Kingdom  UCB Pharma, Slough, UK, Slough , United Kingdom  University Health Network, Toronto, ON, Canada, Toronto, ON, Canada  

Overview of the Safety Profile from Efgartigimod Clinical Trials in Participants with Diverse IgG-mediated Autoimmune Diseases

Author:Vu, Tuan   Gwathmey, Kelly   Broome, Catherine   Goebeler, Matthias   Murai, Hiroyuki   Bata-Csörgo, Zsuzsanna   Newland, Adrian   Ulrichts, Peter   Kerstens, Rene   Guptill, Jeffrey T.   Agha, Sofiane   Jiang, Ming   Howard, James   

Session Name:P4: Autoimmune Neurology: Peripheral Autoimmunity  

Topic:Autoimmune Neurology  

Program Number:P4.016  

Author Institution:University of South Florida, Tampa, FL  Virginia Commonwealth University, Henrico, VA  Georgetown University, Washington, DC  University Hospital Würzburg, Würzburg, Germany  International University of Health and Welfare, Narita, Japan  University of Szeged, Szeged, Hungary  Barts and the London School of Medicine and Dentistry, London, United Kingdom  argenx, Boston, MA  argenx, Ghent , Belgium  argenx, Ghent, Belgium  The University of North Carolina, Dept of Neurology, CB 7025, Chapel Hill, NC