2024 American Academy of Neurology Abstract Website

Objective:

Describe the spectrum and prevalence of Cognitive impairment (CI) phenotypes in MS, potential risk factors and their relationship with Expanded sustainable scale disability (EDSS) and Functional Systems Score.

Background:

Cognitive impairment (CI) is recognized as a prevalent and disabling symptom in Multiple Sclerosis (MS), compromising activities of daily living employability, social life and adherence to treatment, sometimes more intensely than physical limitations themselves.The variability of cognitive impairment in the literature was variable and are not describe all the spectrum this disabilities, from mild symptoms to dementia with serious impairment of quality of life

Design/Methods:

A sample of 117people with MS (PwMS)from a university reference center was selected, diagnosed accordingto McDonald’s revised criteria and evaluated cognitively, psychologically and functionally with the following instruments: Brief Repeatable Battery of Neuropsychological Tests in Multiple Sclerosis (BRB-N), Beck Depression Inventory- 2ª edition (BDI-II), Beck Anxiety Inventory (BAI), EDSS and FSS.There was tree groups in the population regarding severity of CI: G1 (mild), G2 (moderate) and G3 (severe). The stoical significance was p ≥ 0,05 or 95% and was approved by Ethics Committee. All procedure was made for one specialized neuropsychologist and neurologist.

Results:

Cognitive Impairment (CC), 60.7% of the total sample presented impairment in more than two cognitive domains, with the remaining 39.3% without cognitive impairment and 23.1% of the sample having 4 or 5 compromised domains. SPMS presented a significantly higher percentage in G3 than in G1 and G2 (50.0% > 4.3% and 9.8% with p < 0.05), demonstrating that patients with the SPMS form are 22 times more likely to be of G3 than those who have the EMRR form..

Conclusions:

MS generates the entire variability of the spectrum of cognitive impairment in patients and can increase the possibility of dementia with MS, with specific characteristics and associated with the motor severity.