Identifying Predictors for Successful Percutaneous Balloon Compression in Trigeminal Neuralgia: A Retrospective Cohort Study
Jessika M. Mendes1, Nilson N. Mendes Neto2, Marcelo Zacarkim3, Sergio Dantas4
1Telemedicos, 2Clinical Investigation, Harvard Medical School, 3Harvard Medical School, 4Onofre Lopes Hospital
Objective:

This study assesses the efficacy of PBC and factors that may impact outcomes.


Background:
Trigeminal neuralgia (TN) is a chronic pain condition that affects the trigeminal nerve. Percutaneous balloon compression (PBC) is a minimally invasive procedure that is used to treat TN.
Design/Methods:

A retrospective cohort study was conducted involving 222 patients who underwent 242 PBC procedures for TN treatment. The study required a mandatory 6-month follow-up period after surgery.


Results:

The mean age of patients was 62.2 years, with a range of 29 to 91 years. The distribution of male and female patients was 43% and 57%, respectively. Patients who experienced transient complications were 1.61 times more likely to achieve long-term pain relief. Hypoesthesia was a common occurrence, reported in 83.8% of cases. Bradycardia was observed in 58.1% of patients during foramen ovale puncture. Transitory complications, including diplopia, otalgia, and tinnitus were reported. Logistic regression demonstrated a significant relationship between hypoesthesia and increased likelihood of pain relief (p < 0.05). Reoperation due to persistent pain was required in only 6.19% of cases. Most notably, 93.7% of patients successfully discontinued Carbamazepine, a medication commonly used to treat TN.

Conclusions:

This study underscores the efficacy and safety of PBC in TN treatment, with 93.7% of patients experiencing pain relief. The marked reduction in Carbamazepine use further supports its effectiveness. Hypoesthesia was the only factor significantly associated with a higher likelihood of pain relief. Due to safety and effectiveness, PBC may be considered a primary surgical treatment for TN, offering significant relief of pain.


10.1212/WNL.0000000000205977