Factors Associated to Intrahospital Mortality in Neurological Infections in a Tertiary Center in Bogota
Juan Martinez Lemus1, Angela Villamil Saldarriaga2, Alejandra Moncaleano Calderón2, Karen Mesa Santamaria3, Maria Reyes3
1The University of Texas Science Center at Houston, 2Hospital Simón Bolívar, 3Hospital Simon Bolivar
Objective:
To establish risk factors associated with mortality and poor outcomes in patients with neuroinfectious disorders a tertiary center in Bogota, Colombia.
Background:
Neuroinfectious disorders continue to be a leading cause of morbidity and mortality in the young population. In underserved areas, higher levels of advanced immunosuppression due to HIV worsen the prognosis of these patients and impose higher rates of intrahospital mortality.
Design/Methods:
Descriptive, cross-sectional study, evaluated patients with neuroinfectious disorders from 2019- 2022. The modified Rankin scale (mRs) was calculated for each patient at the time of the last evaluation. Parametric and non-parametric tests were used to analyze risk factors associated to poor outcomes (mRs > 3) and death (mRs=6) by the time of discharge.
Results:
We identified a total of 200 patients with a median age of 37 (IQR 28-55). Most of the patients were male (n=152, 76%) and the migrant population constituted approximately 20% of our cohort (n=41, 20.5%). Immunosuppression due to Human Immunodeficiency Virus (HIV) was documented in 125 (62.5%) patients. The percentage of intrahospital mortality was 26.5% (n=41) with a median of 38 years (IQR 31-77). Factors associated with mortality were lower CD4 counts (0.053), especially if lower than 200 (p=0.039), and the absence of antiretroviral therapy (p=0.084).
Conclusions:
Neuroinfectious disorders continue to impose high mortality rates in the young population, especially in underserved areas where advanced HIV is prevalent.