To present a case of new-onset hemicrania continua headache after COVID-19 infection.

COVID-19 can lead to a variety of neurological sequelae, including the worsening of migraine headaches or the development of new onset headaches. While post-COVID-19 cough-induced, migraine, and tension type headaches have been previously reported, there are no reports of post-COVID hemicrania continua headaches.

We present a case of a 57-year-old male who developed a unilateral left side-locked headache with ipsilateral autonomic symptoms after a two-week hospitalization for COVID-19. His headaches were associated with ipsilateral scalp allodynia, tearing, ptosis, and photophobia. An MRI brain with and without contrast showed no acute abnormalities and no masses nor enhancements along the trigeminal nerve. His headaches responded fully to treatment with 75 mg indomethacin three times a day and 600 mg gabapentin three times a day.

To our knowledge, no case reports of post-COVID new onset hemicrania continua headaches have been documented in the literature. This case demonstrates that the breadth of COVID-induced headaches is quite large, and that hemicrania continua headaches should be included on the differential for post-COVID headaches. This case also exemplifies the need for diagnostic criteria for post-COVID headaches.