Efficacy of Cognitive Behavioral Therapy for Anxiety and Depression in Parkinson's Disease
Objective:
To asses the efficacy of CognitiveBehavioralTherapy forAnxiety and Depression in Parkinson's Disease
Background:
In Parkinson's disease (PD), non-motor symptoms like depression and anxiety significantly affect patients' well-being. Existing pharmacological treatments have limitations, driving interest in non-pharmacological options. This systematic review and meta-analysis evaluated the effectiveness of cognitive-behavioral therapy (CBT) in mitigating depression and anxiety in PD patients, suggesting it as a valuable alternative intervention to address these challenging symptoms.
Design/Methods:
We conducted a systematic review up to April 2023, using PubMed, Web of Science, and Scopus to assess the effectiveness of cognitive-behavioral therapy (CBT) for depression and anxiety in Parkinson's disease. Duplicate removal, Risk of Bias-2 (ROB-2) assessment, and meta-analysis with Review 5.4.1 were employed for data accuracy and analysis.
Results:
Thi s systematic review encompassed twelve studies that involved a total of 241 patients with Pa r k i nson' s d i sea se (PD ). CBT resulted i n a substantial reduction in anxiety (SMD -0.95, 95% CI [ -1.15 to -0.74], P<0.00001) and depression (SMD -1.02, 95% CI [-1.39 to -0.65], P<0.0001). The results highlighted the ef fectiveness of both Telephonedelivered Cognitive Behavioral Therapy (tele-CBT) a nd tra d iti ona l CBT i n ef fec ti vel y trea ti ng depression and anxiety. Tele-CBT (SMD -0.90, 95% CI [-1.31 to -0.48], P<0.00001) and traditional CBT (SMD -1.16, 95% CI [-1.83 to -0.49], P < 0.00001). In terms of anxiety, the results indicated traditional CBT (SMD -0.94, 95% CI [-1.25 to -0.63], P<0.00001) and tele-CBT (SMD -0.95, 95% CI [-1.22 to − -0.67], P<0.00001).
Conclusions:
This systematic review and meta-analysis confirmed CBT's effectiveness in reducing depression and anxiety in PD patients. Healthcare providers should consider integrating CBT into PD treatment, but more high-quality, long-term studies are required for a comprehensive understanding.